CAJ | 학술논문

目的探讨阿托伐他汀治疗心力衰竭并阵发性心房颤动的临床疗效.方法选择心力衰竭并阵发性心房颤动的患者108例,随机分为治疗组(常规治疗+阿托伐他汀组,54例)及对照组(常规治疗组,54例).治疗并随访半年,比较治疗前后左室射血分数(LVEF)、C-反应蛋白(CRP)和脑钠肽(BNP)水平变化.结果治疗6个月后,治疗组LVEF明显高于对照组,差异有统计学意义(P＜0.05)；对照组CRP、BNP水平明显高于治疗组,差异有统计学意义(P＜0.05).结论阿托伐他汀能改善心功能,有效降低血中CRP及BNP水平,减少心房颤动的复发.
목적 탐토아탁벌타정치료심력쇠갈병진발성심방전동적림상료효.방법 선택심력쇠갈병진발성심방전동적환자108례,수궤분위치료조(상규치료+아탁벌타정조,54례)급대조조(상규치료조,54례).치료병수방반년,비교치료전후좌실사혈분수(LVEF)、C-반응단백(CRP)화뇌납태(BNP)수평변화.결과 치료6개월후,치료조LVEF명현고우대조조,차이유통계학의의(P＜0.05)；대조조CRP、BNP수평명현고우치료조,차이유통계학의의(P＜0.05).결론 아탁벌타정능개선심공능,유효강저혈중CRP급BNP수평,감소심방전동적복발.
Objective To investigate the clinical therapeutic effect of atorvastatin on patients with heart failure and paroxysmal atrial fibrillation.Methods One hundred and eight patients with heart failure and paroxysmal atrial fibrillation were divided into atorvastatin group (cony-entional therapy and atorvastatin,n =54) and control group (conventional therapy,n =54) randomly.The follow-up duration for every patient was half one year.Change of the left ventricular ejection fraction,C-reactive protein (CRP) and brain natriuretic pep tide (BNP) were observed before and after treatment.Results After half one year,the left ventricular ejection fraction of atorvastatin group was significantly higher than that of control group(P ＜0.05).The level of CRP and BNP of control group was significantly higher than that of atorvastatin group (P ＜ 0.05).Conclusions Atorvastatin may improve the heart function and depress the level of CRP and BNP in blood and decrease the recidivation of paroxysmal atrial fibrillation.