中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
8期
8-9
,共2页
氯吡格雷%抗血小板%经皮冠状动脉介入治疗
氯吡格雷%抗血小闆%經皮冠狀動脈介入治療
록필격뢰%항혈소판%경피관상동맥개입치료
Clopidogrel%Antiplatelet%Percutaneous coronary intervention
目的 观察国产和进口氯吡格雷对冠心病患者经皮冠状动脉介入治疗(PCI)术后抗血小板的临床疗效和安全性.方法 将408例冠心病患者随机分为两组,其中国产氯吡格雷治疗组210例,进口氯吡格雷治疗组198例,两组患者均于PCI术前3d开始服用氯吡格雷,首剂300 mg,以后每日75 mg,共服用12个月.观察两组患者PCI术后急性血栓、亚急性血栓、晚期血栓的发生率；术后主要心血管不良事件包括心源性死亡、再次心肌梗死、再发心绞痛、继发心力衰竭及再次入院治疗、术后再狭窄及临床出血事件包括脑出血、消化道出血及皮下出血的对比情况.结果 两组患者的主要不良心脏事件及各种出血并发症比较差异无统计学意义.结论 国产和进口两种氯吡格雷的临床疗效相同,安全可靠.
目的 觀察國產和進口氯吡格雷對冠心病患者經皮冠狀動脈介入治療(PCI)術後抗血小闆的臨床療效和安全性.方法 將408例冠心病患者隨機分為兩組,其中國產氯吡格雷治療組210例,進口氯吡格雷治療組198例,兩組患者均于PCI術前3d開始服用氯吡格雷,首劑300 mg,以後每日75 mg,共服用12箇月.觀察兩組患者PCI術後急性血栓、亞急性血栓、晚期血栓的髮生率；術後主要心血管不良事件包括心源性死亡、再次心肌梗死、再髮心絞痛、繼髮心力衰竭及再次入院治療、術後再狹窄及臨床齣血事件包括腦齣血、消化道齣血及皮下齣血的對比情況.結果 兩組患者的主要不良心髒事件及各種齣血併髮癥比較差異無統計學意義.結論 國產和進口兩種氯吡格雷的臨床療效相同,安全可靠.
목적 관찰국산화진구록필격뢰대관심병환자경피관상동맥개입치료(PCI)술후항혈소판적림상료효화안전성.방법 장408례관심병환자수궤분위량조,기중국산록필격뢰치료조210례,진구록필격뢰치료조198례,량조환자균우PCI술전3d개시복용록필격뢰,수제300 mg,이후매일75 mg,공복용12개월.관찰량조환자PCI술후급성혈전、아급성혈전、만기혈전적발생솔；술후주요심혈관불량사건포괄심원성사망、재차심기경사、재발심교통、계발심력쇠갈급재차입원치료、술후재협착급림상출혈사건포괄뇌출혈、소화도출혈급피하출혈적대비정황.결과 량조환자적주요불양심장사건급각충출혈병발증비교차이무통계학의의.결론 국산화진구량충록필격뢰적림상료효상동,안전가고.
Objective To observe the curative effects and safety of home-made clopidogrel (Talcom) and imported clopidogrel (Plavix) in patients underwent percutaneous transluminal coronary implantation(PCI).Methods A total of 408 coronary heart disease (CHD)patients were randomly divided into two groups including Talcom group(n =210)and Plavix group(n =198).Clopidogrel were given to all CHD patients 3 days before PCI.The first dosage of 300 mg was taken,then 75 mg/d for one year.The events of acute-subacute and late thrombosis in stent were observed.The bleeding events and vascular restenosis were also observed.Results There were no significant differences of the incidences of acute,subacute,late thrombosis and bleeding events in stent of two groups during 12 months after PCI.Conclusions Home-made clopidogrel and imported clopidogrel are both effective and safe for the treatment of patients underwent PCI.
