中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
8期
56-58
,共3页
李帅兵%杨帆%荆莉%马娟%贾亚丹%董少英%郑卫峰%赵洛沙
李帥兵%楊帆%荊莉%馬娟%賈亞丹%董少英%鄭衛峰%趙洛沙
리수병%양범%형리%마연%가아단%동소영%정위봉%조락사
X综合征%血尿酸%C-反应蛋白
X綜閤徵%血尿痠%C-反應蛋白
X종합정%혈뇨산%C-반응단백
Syndrome X%Serum uric acid%C-reactive protein
目的 探讨血尿酸和C-反应蛋白水平在x综合征中的作用.方法 选择郑州大学第一附属医院2011年8月至2012年4月心血管内科住院的87例被诊断为X综合征的患者作为试验组,另选择34例无症状的正常人作为对照组,采用ELISA方法及酶比色法分别测定C-反应蛋白水平和血尿酸浓度.结果 与对照组相比,试验组的血尿酸水平[(8.8±0.9)vs(5.0±0.9) mg/L,P=0.041]、C-反应蛋白水平[(10.5±4.8) vs(3.4±1.3) mg/L,P＜0.01]、总胆固醇[(201 ±44) vs(170±24) mg/dl,P=0.021]和三酰甘油[(179±113)vs(123±17) mg/dl,P=0.038]均显著增加.相关性分析结果显示:血尿酸与三酰甘油(r=0.384,P=0.032)呈显著正相关；高敏C-反应蛋白与总胆固醇(r=0.456,P＜0.01)、低密度脂蛋白胆固醇(r=0.442,P＜0.01)呈显著正相关,与高密度脂蛋白胆固醇(r=-0.321,P=0.042)呈显著负相关.结论 血尿酸水平及炎症因素都可能参与X综合征的发生、发展.
目的 探討血尿痠和C-反應蛋白水平在x綜閤徵中的作用.方法 選擇鄭州大學第一附屬醫院2011年8月至2012年4月心血管內科住院的87例被診斷為X綜閤徵的患者作為試驗組,另選擇34例無癥狀的正常人作為對照組,採用ELISA方法及酶比色法分彆測定C-反應蛋白水平和血尿痠濃度.結果 與對照組相比,試驗組的血尿痠水平[(8.8±0.9)vs(5.0±0.9) mg/L,P=0.041]、C-反應蛋白水平[(10.5±4.8) vs(3.4±1.3) mg/L,P＜0.01]、總膽固醇[(201 ±44) vs(170±24) mg/dl,P=0.021]和三酰甘油[(179±113)vs(123±17) mg/dl,P=0.038]均顯著增加.相關性分析結果顯示:血尿痠與三酰甘油(r=0.384,P=0.032)呈顯著正相關；高敏C-反應蛋白與總膽固醇(r=0.456,P＜0.01)、低密度脂蛋白膽固醇(r=0.442,P＜0.01)呈顯著正相關,與高密度脂蛋白膽固醇(r=-0.321,P=0.042)呈顯著負相關.結論 血尿痠水平及炎癥因素都可能參與X綜閤徵的髮生、髮展.
목적 탐토혈뇨산화C-반응단백수평재x종합정중적작용.방법 선택정주대학제일부속의원2011년8월지2012년4월심혈관내과주원적87례피진단위X종합정적환자작위시험조,령선택34례무증상적정상인작위대조조,채용ELISA방법급매비색법분별측정C-반응단백수평화혈뇨산농도.결과 여대조조상비,시험조적혈뇨산수평[(8.8±0.9)vs(5.0±0.9) mg/L,P=0.041]、C-반응단백수평[(10.5±4.8) vs(3.4±1.3) mg/L,P＜0.01]、총담고순[(201 ±44) vs(170±24) mg/dl,P=0.021]화삼선감유[(179±113)vs(123±17) mg/dl,P=0.038]균현저증가.상관성분석결과현시:혈뇨산여삼선감유(r=0.384,P=0.032)정현저정상관；고민C-반응단백여총담고순(r=0.456,P＜0.01)、저밀도지단백담고순(r=0.442,P＜0.01)정현저정상관,여고밀도지단백담고순(r=-0.321,P=0.042)정현저부상관.결론 혈뇨산수평급염증인소도가능삼여X종합정적발생、발전.
Objective To investigate the role of serum uric acid and serum high-sensitive C-reactive protein (hs-CRP) in syndrome X.Methods Eighty-seven patients with attacks of chest pain diagnosed as syndrome X(study group) and 34 normal asymptomatic subjects (control group) from Augest 2011 to April 2012 in the first affiliated hospital of Zhengzhou universigy were selected.Serum hs-CRP and uric acid levels were assessed in all subjects.Results The mean hs-CRP level was higher in the study group,compared to controls [(10.5 ± 4.8) versus (3.4 ± 1.3) mg/L,P ＜ 0.01].Total cholesterol [(201 ± 44) versus (170 ± 24) mg/dl,P =0.021] and triglyceride levels [(179 ± 113) versus (123 ± 17) mg/dl,P =0.038] were higher in the patients compared with controls ; Furthermore,there was statistically significant difference in mean serum uric acid levels [(8.8 ± 0.9)versus (5.0 ±0.9) mg/L,P =0.041] between the two groups.Pearson correlation analysis showed that serum uric acid was positively correlated with serum TG values(r =0.384,P =0.032) ; serum hs-CRP was positively correlated with TC(r =0.456,P ＜0.01) and LDL-C(r =0.442,P ＜0.01),and negatively with HDL-C (r =-0.321,P =0.042).Conclusions Syndrome X may have an inflammatory element (reflected as a higher serum hs-CRP level) ; Furthermore,serum uric acid is possibly associated with syndrome X.
