中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
10期
1-3
,共3页
上官佳红%李凌%陶海龙%赵荫涛
上官佳紅%李凌%陶海龍%趙蔭濤
상관가홍%리릉%도해룡%조음도
同型半胱氨酸%冠心病%骨质疏松%老年%骨密度
同型半胱氨痠%冠心病%骨質疏鬆%老年%骨密度
동형반광안산%관심병%골질소송%노년%골밀도
Homocysteine%Coronary heart disease%Osteoporosis%Elderly%Bone mineral density
目的 探讨血浆同型半胱氨酸(Hcy)与老年冠心病合并骨质疏松的关系.方法 98例老年冠心病患者按照骨密度(BMD)平均T值分为三组:骨质疏松组(A组)29例,骨量减少组(B组)37例及骨量正常组(C组)32例.另选取健康对照组(D组)25例,分别比较各组收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、体质量指数(BMI)、Hcy、血钙、血磷及超敏C-反应蛋白(hs-CRP)水平.结果 A组和B组Hcy水平明显高于C组和D组,且A组高于B组,C组高于D组(P＜0.05)；血浆Hcy水平与BMD呈负相关(r=-0.581,P ＜0.05)；BMI与骨质疏松是影响Hcy的重要因素(回归系数b1=-0.68,b2=3.459,P＜0.05).结论 老年冠心病合并骨质疏松患者血浆Hcy升高可能与其BMD减低有关,Hcy水平可能为老年冠心病患者骨质疏松的独立危险因素之一.
目的 探討血漿同型半胱氨痠(Hcy)與老年冠心病閤併骨質疏鬆的關繫.方法 98例老年冠心病患者按照骨密度(BMD)平均T值分為三組:骨質疏鬆組(A組)29例,骨量減少組(B組)37例及骨量正常組(C組)32例.另選取健康對照組(D組)25例,分彆比較各組收縮壓(SBP)、舒張壓(DBP)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、總膽固醇(TC)、體質量指數(BMI)、Hcy、血鈣、血燐及超敏C-反應蛋白(hs-CRP)水平.結果 A組和B組Hcy水平明顯高于C組和D組,且A組高于B組,C組高于D組(P＜0.05)；血漿Hcy水平與BMD呈負相關(r=-0.581,P ＜0.05)；BMI與骨質疏鬆是影響Hcy的重要因素(迴歸繫數b1=-0.68,b2=3.459,P＜0.05).結論 老年冠心病閤併骨質疏鬆患者血漿Hcy升高可能與其BMD減低有關,Hcy水平可能為老年冠心病患者骨質疏鬆的獨立危險因素之一.
목적 탐토혈장동형반광안산(Hcy)여노년관심병합병골질소송적관계.방법 98례노년관심병환자안조골밀도(BMD)평균T치분위삼조:골질소송조(A조)29례,골량감소조(B조)37례급골량정상조(C조)32례.령선취건강대조조(D조)25례,분별비교각조수축압(SBP)、서장압(DBP)、삼선감유(TG)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、총담고순(TC)、체질량지수(BMI)、Hcy、혈개、혈린급초민C-반응단백(hs-CRP)수평.결과 A조화B조Hcy수평명현고우C조화D조,차A조고우B조,C조고우D조(P＜0.05)；혈장Hcy수평여BMD정부상관(r=-0.581,P ＜0.05)；BMI여골질소송시영향Hcy적중요인소(회귀계수b1=-0.68,b2=3.459,P＜0.05).결론 노년관심병합병골질소송환자혈장Hcy승고가능여기BMD감저유관,Hcy수평가능위노년관심병환자골질소송적독립위험인소지일.
Objective To investigate the relationship between plasma homocysteine (Hcy) and elderly coronary heart disease patients with osteoporoisis.Methods Ninety-eight elderly patients with coronary heart disease were divided into three groups according to the average T value of bone mineral density(BMD):patients in group A(29 cases) were osteoporosis group,patients in group B(37 cases)were osteopenia group,and patients in group C(32 cases) were normal group.Twenty-five healthy cases as normal control group(group D).SBP,DBP,TG,LDL-C,HDL-C,TC,BMI,Hcy,blood calcium,blood phosphorus and hs-CRP levels were compared among the four groups.Results Levels of plasma Hcy in group A and group B were higher than those in group C and group D,and that in group A was higher than that group B,in group C was higher than that in group D (P ＜ 0.05).BMD was negatively correlated with plasma Hcy(r =-0.581,P ＜0.05).BMI and osteoporosis were the risk factors that affected Hcy(b1 =-0.68,b2 =3.459,P ＜ 0.05).Conclusions Elevated plasma Hcy levels in elderly coronary heart disease patients with osteoporosis may be correlated with the decrease of BMD.Hcy level may be independent risk factor for osteoporosis in coronary heart disease patients.
