中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
10期
28-30
,共3页
何志恩%邓少剑%饶艳%张理宾
何誌恩%鄧少劍%饒豔%張理賓
하지은%산소검%요염%장리빈
帕瑞昔布钠%躁动%疼痛
帕瑞昔佈鈉%躁動%疼痛
파서석포납%조동%동통
Parecoxib%Agitation%Pain
目的 观察帕瑞昔布钠对腹腔镜阑尾切除患者全麻苏醒期躁动和疼痛的影响.方法 全身麻醉下行择期腹腔镜阑尾切除术患者50例,年龄20 ～ 50岁,体质量45～ 70 kg,ASA Ⅰ～Ⅱ级.随机均分为两组,双盲对照观察.术毕前20 min静脉用帕瑞昔布钠40 mg为P组、术毕前20 min静脉用生理盐水2 ml为C组.观察患者睁眼时间、拔管时间；拔管后1 h(T1)、术后4 h(T2)、术后12 h(T3)、术后24 h(T4) VAS评分、苏醒期躁动评分(RS)、Ram say镇静评分(RSS)以及术后不良反应的发生.结果 P组和C组睁眼、拔管时间比较差异无统计学意义(P＞0.05)；P组T1、T2、T3、T4时段VAS评分明显低于C组(P＜0.05)；P组的苏醒期躁动评分(RS)明显低于C组(P＜0.05)、P组的镇静评分(RSS)明显高于C组(P＜0.05)；各组术后不良反应的发生率比较差异无统计学意义(P＞0.05).结论 腹腔镜阑尾切除术中使用帕瑞昔布钠具有良好的镇痛以及减少患者苏醒时躁动的作用,同时并不增加苏醒时间和术后的不良反应发生率.
目的 觀察帕瑞昔佈鈉對腹腔鏡闌尾切除患者全痳囌醒期躁動和疼痛的影響.方法 全身痳醉下行擇期腹腔鏡闌尾切除術患者50例,年齡20 ～ 50歲,體質量45～ 70 kg,ASA Ⅰ～Ⅱ級.隨機均分為兩組,雙盲對照觀察.術畢前20 min靜脈用帕瑞昔佈鈉40 mg為P組、術畢前20 min靜脈用生理鹽水2 ml為C組.觀察患者睜眼時間、拔管時間；拔管後1 h(T1)、術後4 h(T2)、術後12 h(T3)、術後24 h(T4) VAS評分、囌醒期躁動評分(RS)、Ram say鎮靜評分(RSS)以及術後不良反應的髮生.結果 P組和C組睜眼、拔管時間比較差異無統計學意義(P＞0.05)；P組T1、T2、T3、T4時段VAS評分明顯低于C組(P＜0.05)；P組的囌醒期躁動評分(RS)明顯低于C組(P＜0.05)、P組的鎮靜評分(RSS)明顯高于C組(P＜0.05)；各組術後不良反應的髮生率比較差異無統計學意義(P＞0.05).結論 腹腔鏡闌尾切除術中使用帕瑞昔佈鈉具有良好的鎮痛以及減少患者囌醒時躁動的作用,同時併不增加囌醒時間和術後的不良反應髮生率.
목적 관찰파서석포납대복강경란미절제환자전마소성기조동화동통적영향.방법 전신마취하행택기복강경란미절제술환자50례,년령20 ～ 50세,체질량45～ 70 kg,ASA Ⅰ～Ⅱ급.수궤균분위량조,쌍맹대조관찰.술필전20 min정맥용파서석포납40 mg위P조、술필전20 min정맥용생리염수2 ml위C조.관찰환자정안시간、발관시간；발관후1 h(T1)、술후4 h(T2)、술후12 h(T3)、술후24 h(T4) VAS평분、소성기조동평분(RS)、Ram say진정평분(RSS)이급술후불량반응적발생.결과 P조화C조정안、발관시간비교차이무통계학의의(P＞0.05)；P조T1、T2、T3、T4시단VAS평분명현저우C조(P＜0.05)；P조적소성기조동평분(RS)명현저우C조(P＜0.05)、P조적진정평분(RSS)명현고우C조(P＜0.05)；각조술후불량반응적발생솔비교차이무통계학의의(P＞0.05).결론 복강경란미절제술중사용파서석포납구유량호적진통이급감소환자소성시조동적작용,동시병불증가소성시간화술후적불량반응발생솔.
Objective To observe the effect of parecoxib on the prevention of agitation and pain during recovery period on general anesthesia after laparoscopic appendectomy.Methods Fifty laparoscopic appendectomy patients with ASA Ⅰ-Ⅱ,age from 20-50 years old,weight 45-70 kg were selected under general anesthesia.They were divided into two groups randomly and were observed by double blind contrast test.The patients in group P were intravenously injected with parecoxib 40 mg at 20 minutes before the end of operation,and the patients in group C were intravenously injected with physiological saline 2 ml.The time of opening eyes,and the time of extubation.VAS about 1 hour after extubation (T1),4 hours after operation(T2),12 hours after operation(T3),24 hours after operation(T4) ; RS and RSS during general anesthesia revival period and adverse reactions after operation were observed.Results There was no obvious difference in the time of awakening and the time of extubation in group P and group C.VAS Scores about T1,T2,T3,T4 in group P were significantly lower than those in group C(P ＜ 0.05).RS in group P was obviously lower than that in group C (P ＜ 0.05) ; RSS in group P was distinctly higher than that in group C (P ＜ 0.05).There was no obvious difference on adverse reactions after operations in each group.Conclusions Parecoxib has good effect on pain-relieving and reducing patients'agitation during general anesthesia revival period in laparoscopic appendectomy operation,and at the same time dose not increase the incidence of adverse reactions after operations.
