CAJ | 학술논문

目的评价瑞舒伐他汀和氟伐他汀分别对绝经期冠心病合并骨质疏松患者血脂、骨密度的影响.方法选取117例绝经期冠心病合并骨质疏松患者,随机分为A组和B组,A组每晚给予瑞舒伐他汀10 mg,B组每晚给予氟伐他汀缓释片80 mg,共随访40周,治疗前后分别测定血脂、骨密度.结果两组患者血总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平均较治疗前明显降低,高密度脂蛋白胆固醇水平明显升高(P＜0.05),A组各项血脂变化幅度较B组明显(P＜0.05).两组治疗后骨密度值均明显增高(P＜0.05).结论瑞舒伐他汀和氟伐他汀对绝经期冠心病伴骨质疏松患者均有良好的调脂作用,瑞舒伐他汀的效果优于氟伐他汀.瑞舒伐他汀和氟伐他汀均可提高绝经期冠心病伴骨质疏松患者的骨密度值.
목적 평개서서벌타정화불벌타정분별대절경기관심병합병골질소송환자혈지、골밀도적영향.방법 선취117례절경기관심병합병골질소송환자,수궤분위A조화B조,A조매만급여서서벌타정10 mg,B조매만급여불벌타정완석편80 mg,공수방40주,치료전후분별측정혈지、골밀도.결과 량조환자혈총담고순、삼선감유、저밀도지단백담고순수평균교치료전명현강저,고밀도지단백담고순수평명현승고(P＜0.05),A조각항혈지변화폭도교B조명현(P＜0.05).량조치료후골밀도치균명현증고(P＜0.05).결론 서서벌타정화불벌타정대절경기관심병반골질소송환자균유량호적조지작용,서서벌타정적효과우우불벌타정.서서벌타정화불벌타정균가제고절경기관심병반골질소송환자적골밀도치.
Objective To investigate the effects of rosuvastatin and fluvastatin on serum lipids,bone mineral density(BMD) in postmenopausal coronary heart disease patients with osteoporosis.Methods One hundred and seventeen cases of postmenopausal coronary heart disease with osteoporosis were randomly divided into group A(n =60) and group B(n =57).Rosuvastatin 10 mg per night were given in group A,fluvastatin 80 mg per night was given in group B.The follow-up lasted for 40 weeks.Serum lipids and bone mineral density were measured before treatment and after 40 weeks.Results Compared with pretherapy,serum total cholesterol,triglycerides,and low density lipoprotein cholesterol were lower,high density lipoprotein cholesterol was higher after treatment in both groups(P ＜ 0.05).Serum lipids in group A were more significant than that in group B (P ＜ 0.05).The parameter value of bone density at lumar vertebrae 2-4 and proximal femur(Neck and Troch) were all significantly increased in two groups (P ＜ 0.05).Conclusions Both rosuvastatin and fluvastatin have satisfactory regulations on hyperlipoidemia in postmenopausal CHD with osteoporosis,and rosuvastatin was superior to fluvastatin.Both rosuvastatin and fluvastatin may increased bone density of postmenopausal CHD with osteoporosis.