中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
10期
35-36
,共2页
伊马替尼耐药%慢性粒细胞白血病%Axl
伊馬替尼耐藥%慢性粒細胞白血病%Axl
이마체니내약%만성립세포백혈병%Axl
Imatinib-resistant%Chronic myeloid leukemia%Axl
目的 探讨Axl与应用伊马替尼耐药的发生关系.方法 选取郑州大学第一附属医院2009年3月至2012年5月慢性粒细胞白血病59例,检测Axl mRNA水平,比较不同预后患者的表达情况.结果 慢性粒细胞白血病患者Axl mRNA的表达水平随着应用伊马替尼治疗效果有所不同,不同治疗效果患者Axl mRNA的表达水平差异有统计学意义(P＜0.05).结论 Axl与慢性粒细胞白血病患者应用伊马替尼治疗耐药有关,Axl的过度表达提示出现伊马替尼耐药发生率较高.
目的 探討Axl與應用伊馬替尼耐藥的髮生關繫.方法 選取鄭州大學第一附屬醫院2009年3月至2012年5月慢性粒細胞白血病59例,檢測Axl mRNA水平,比較不同預後患者的錶達情況.結果 慢性粒細胞白血病患者Axl mRNA的錶達水平隨著應用伊馬替尼治療效果有所不同,不同治療效果患者Axl mRNA的錶達水平差異有統計學意義(P＜0.05).結論 Axl與慢性粒細胞白血病患者應用伊馬替尼治療耐藥有關,Axl的過度錶達提示齣現伊馬替尼耐藥髮生率較高.
목적 탐토Axl여응용이마체니내약적발생관계.방법 선취정주대학제일부속의원2009년3월지2012년5월만성립세포백혈병59례,검측Axl mRNA수평,비교불동예후환자적표체정황.결과 만성립세포백혈병환자Axl mRNA적표체수평수착응용이마체니치료효과유소불동,불동치료효과환자Axl mRNA적표체수평차이유통계학의의(P＜0.05).결론 Axl여만성립세포백혈병환자응용이마체니치료내약유관,Axl적과도표체제시출현이마체니내약발생솔교고.
Objective To investigate the relationship between Axl and imatinib resistance.Methods Fifty-nine cases of chronic myeloid leukemia in the first affiliated hospital of Zhengzhou university between March 2009 and May 2012 were selected.The level of Axl mRNA was detected,and the expression levels of patients with different prognosis were compared.Results With the different efficacy of imatinib,Axl mRNA expression level of chronic myeloid leukemia patients were different.Axl mRNA expression levels had significant difference among patients with different treatment effect (P ＜ 0.05).Conclusions Axl is related to imatinib resistance in chronic myeloid leukemia patients.And the overexpression of Axl predicted the high incidence rate of matinib resistance.
