CAJ | 학술논문

目的研究干扰素类型及丙肝病毒载量对慢性丙型肝炎抗病毒治疗应答的影响.方法选择297例慢性丙型肝炎患者为研究对象,对抗病毒治疗的应答情况与干扰素类型及丙肝病毒载量的关系进行回顾性分析.结果在HCV RNA≥105 IU/ml组,聚乙二醇干扰素α-2a抗病毒治疗获得快速病毒学应答(RVR)率为74.7％,早期病毒学应答率(EVR)为81.6％,普通干扰素α-2b组RVR获得率为58.7％,EVR获得率为62.5％,组间比较差异有统计学意义(P＜0.05).而在HCVRNA＜105 IU/ml组,聚乙二醇干扰素α-2a组获RVR率为80.9％,EVR率为88.2％,普通干扰素α-2b组获RVR率为80.6％,EVR率为85.5％,组间比较差异无统计学意义(P＞0.05).结论在病毒载量较高的情况下,聚乙二醇干扰素α-2a针较普通干扰素α-2b针抗病毒治疗的RVR及EVR获得率高.而在病毒载量较低的情况下,聚乙二醇干扰素α-2a针与普通干扰素α-2b针抗病毒治疗的RVR及EVR获得率差异无统计学意义.
목적 연구간우소류형급병간병독재량대만성병형간염항병독치료응답적영향.방법 선택297례만성병형간염환자위연구대상,대항병독치료적응답정황여간우소류형급병간병독재량적관계진행회고성분석.결과 재HCV RNA≥105 IU/ml조,취을이순간우소α-2a항병독치료획득쾌속병독학응답(RVR)솔위74.7％,조기병독학응답솔(EVR)위81.6％,보통간우소α-2b조RVR획득솔위58.7％,EVR획득솔위62.5％,조간비교차이유통계학의의(P＜0.05).이재HCVRNA＜105 IU/ml조,취을이순간우소α-2a조획RVR솔위80.9％,EVR솔위88.2％,보통간우소α-2b조획RVR솔위80.6％,EVR솔위85.5％,조간비교차이무통계학의의(P＞0.05).결론 재병독재량교고적정황하,취을이순간우소α-2a침교보통간우소α-2b침항병독치료적RVR급EVR획득솔고.이재병독재량교저적정황하,취을이순간우소α-2a침여보통간우소α-2b침항병독치료적RVR급EVR획득솔차이무통계학의의.
Objective To investigate the effect of interferon types and hepatitis C viral load on anti-viral treatment response of chronic hepatitis C.Methods The clinical data of 297 chronic hepatitis C who received antiviral treatment was studied,the correlation of response condition with interferon types and hepatitis C viral load was retrospectively analyzed.Results In HCV RNA above 105 IU/ml case,pegylated interferon α-2a received RVR was 74.7％,EVR was 81.6％,ordinary interferon α-2b received RVR was 58.7％,EVR was 62.5％.In HCV RNA below 105 IU/ml case,pegylated interferon α-2a received RVR was 80.9％,EVR was 88.2％,ordinary interferon α-2b received RVR was 80.6％,EVR was 85.5％.Conclusions When HCV RNA load was higher,pegylated interferon α-2a received higher rapid virological rate and early virological response than ordinary interferon α-2b.When HCV RNA load was lower,interferon type response to antiviral therapy was not statistically significant.