CAJ | 학술논문

目的探讨左炔诺孕酮宫内缓释系统(LNG-IUS,商业名曼月乐)治疗子宫腺肌病的临床疗效及不良反应.方法随访2010年8月至2012年4月期间在郑州大学第三附属医院门诊就诊的宫内放置曼月乐环的53例患有子宫腺肌病患者,观察曼月乐环放置前及放置后的1、3、6个月的痛经评分、PBAC月经量评分、子宫体积及内膜厚度等多项改变及使用曼月乐环后相关的不良反应.结果曼月乐治疗前后患者痛经症状显著减轻(P＜0.01),月经量显著减少(P＜0.01),子宫内膜变薄(P＜0.01)；子宫体积稍有缩小,但差异无统计学意义(P＞0.05).伴随阴道不规则点滴出血、围绝经期症状、阴道干燥、骨质疏松等不良反应.结论左炔诺孕酮宫内缓释系统是治疗子宫腺肌病的一种有效治疗方法.
목적 탐토좌결낙잉동궁내완석계통(LNG-IUS,상업명만월악)치료자궁선기병적림상료효급불량반응.방법 수방2010년8월지2012년4월기간재정주대학제삼부속의원문진취진적궁내방치만월악배적53례환유자궁선기병환자,관찰만월악배방치전급방치후적1、3、6개월적통경평분、PBAC월경량평분、자궁체적급내막후도등다항개변급사용만월악배후상관적불량반응.결과 만월악치료전후환자통경증상현저감경(P＜0.01),월경량현저감소(P＜0.01),자궁내막변박(P＜0.01)；자궁체적초유축소,단차이무통계학의의(P＞0.05).반수음도불규칙점적출혈、위절경기증상、음도간조、골질소송등불량반응.결론 좌결낙잉동궁내완석계통시치료자궁선기병적일충유효치료방법.
Objective To investigate the clinical effect and sides effects of levonorgestrel-releasing intrauterine(Mirena) in the treatment of adenomyosis.Methods Fifty-three cases of adenomyosis treated with levonorgestrel-releasing intrauterine system in the third affiliated hospital of Zhengzhou university during August 2010 and April 2012 were followed-up.The change of dysmenorrhea and menstrual volume,sides effects before and after 1,3,6 months insertion respectively were observed.Results The grades of both postoperative dysmenorrhea,menstrual volume and endometrial thickness markedly decreased,with statistical significance (P ＜ 0.01).The uterine volume slightly reduced,but there was no statistical significant differece before and after treatment (P ＞ 0.05).The main side effects were little vaginal bleeding,menopausal symptom,colpoxerosis,osteoporosis and so on.Conclusions Mirena was an effective method in the treatment of adenomyosis.