中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
11期
49-51
,共3页
儿童非霍奇金淋巴瘤%病理分型%临床分期%诊疗%预后
兒童非霍奇金淋巴瘤%病理分型%臨床分期%診療%預後
인동비곽기금림파류%병리분형%림상분기%진료%예후
Childhood non-Hodgkin' s lymphoma%Pathological classification%Clinical stage%Diagnosis and treatment%Prognosis
目的 探讨儿童非霍奇金淋巴瘤(NHL)的临床、病理特点、诊疗及预后.方法 回顾性分析2006年1月至2011年12月郑州大学第一附属医院诊治的65例NHL患儿的临床表现、病理分型、治疗及预后,并对其进行总结.结果 病理分型以前驱淋巴母细胞型淋巴瘤(35.38％)、Burkitt's型淋巴瘤(36.92％)、T细胞性间变大细胞型淋巴瘤(12.30％)为主,不同亚型NHL原发部位不同呈现出不同的临床表现及体征.本研究临床分期多为Ⅲ 期(40.68％)和Ⅳ期(45.76％).随访53例患儿,随访时间1～6年.Ⅰ期和Ⅱ期患儿1、3、5年生存率分别为100％、87.50％、87.50％；Ⅲ期和Ⅳ期1、3、5年生存率分别为78.43％、62.75％、49.02％.结论 儿童NHL临床表现、病理分型多样化,呈现高度侵袭性过程,多数初诊已是Ⅲ期或Ⅳ期.病理学检查仍是NHL最基本和最重要的诊断手段.应根据患几病理分型、临床分期、分组选用相应的治疗方案,多药联合化疗为主,必要时手术或放疗.预后与病理分型、临床分期、预后不良因素密切相关,具体因素与预后的相关性如何尚需大样本的临床研究.
目的 探討兒童非霍奇金淋巴瘤(NHL)的臨床、病理特點、診療及預後.方法 迴顧性分析2006年1月至2011年12月鄭州大學第一附屬醫院診治的65例NHL患兒的臨床錶現、病理分型、治療及預後,併對其進行總結.結果 病理分型以前驅淋巴母細胞型淋巴瘤(35.38％)、Burkitt's型淋巴瘤(36.92％)、T細胞性間變大細胞型淋巴瘤(12.30％)為主,不同亞型NHL原髮部位不同呈現齣不同的臨床錶現及體徵.本研究臨床分期多為Ⅲ 期(40.68％)和Ⅳ期(45.76％).隨訪53例患兒,隨訪時間1～6年.Ⅰ期和Ⅱ期患兒1、3、5年生存率分彆為100％、87.50％、87.50％；Ⅲ期和Ⅳ期1、3、5年生存率分彆為78.43％、62.75％、49.02％.結論 兒童NHL臨床錶現、病理分型多樣化,呈現高度侵襲性過程,多數初診已是Ⅲ期或Ⅳ期.病理學檢查仍是NHL最基本和最重要的診斷手段.應根據患幾病理分型、臨床分期、分組選用相應的治療方案,多藥聯閤化療為主,必要時手術或放療.預後與病理分型、臨床分期、預後不良因素密切相關,具體因素與預後的相關性如何尚需大樣本的臨床研究.
목적 탐토인동비곽기금림파류(NHL)적림상、병리특점、진료급예후.방법 회고성분석2006년1월지2011년12월정주대학제일부속의원진치적65례NHL환인적림상표현、병리분형、치료급예후,병대기진행총결.결과 병리분형이전구림파모세포형림파류(35.38％)、Burkitt's형림파류(36.92％)、T세포성간변대세포형림파류(12.30％)위주,불동아형NHL원발부위불동정현출불동적림상표현급체정.본연구림상분기다위Ⅲ 기(40.68％)화Ⅳ기(45.76％).수방53례환인,수방시간1～6년.Ⅰ기화Ⅱ기환인1、3、5년생존솔분별위100％、87.50％、87.50％；Ⅲ기화Ⅳ기1、3、5년생존솔분별위78.43％、62.75％、49.02％.결론 인동NHL림상표현、병리분형다양화,정현고도침습성과정,다수초진이시Ⅲ기혹Ⅳ기.병이학검사잉시NHL최기본화최중요적진단수단.응근거환궤병리분형、림상분기、분조선용상응적치료방안,다약연합화료위주,필요시수술혹방료.예후여병리분형、림상분기、예후불량인소밀절상관,구체인소여예후적상관성여하상수대양본적림상연구.
Objective To investigate the clinical and pathological features,diagnosis,treatment and prognosis of childhood non-Hodgkin's lymphoma.Methods Sixty-five children with NHL,admitted to the first affiliated hospital of zhengzhou university from January 2006 to December 2011,were enrolled in the study.The clinical manifestation,pathological classification,treatment and prognosis was retrospectively analyzed.Results The most common pathological subtypes were lymphoblastic lymphoma (35.38％),Burkitt' s lymphoma(36.92％),anaplastic large cell lymphoma(12.30％).Different subtype had different primary site and showed different clinical manifestation and sign.Most cases were in stage m (40.68％) and stageⅣ (45.76％).Fifty-three cases were followed up,the duration was from one year up to six years.The 1,3,5 year survival rate was respectively 100％,87.50％,87.50％ in stage Ⅰ and Ⅱ,78.43％,62.75％,49.02％ in stage Ⅲ and Ⅳ.Conclusions Childhood NHL show diversification in clinical manifestation and pathological classification and presents a highly invasive process.Most patients were in stage Ⅲ or Ⅳ when newly diagnosed.Pathological examination is still the most basic and important diagnostic tool for NHL.Appropriate therapeutic regimen should be selected based on pathological type,clinical stage and grouping of children.Multi-drug combination chemotherapy is given mainly,if necessary surgery or radiotherapy.The Prognosis is closely related with pathological type,clinical stage,and poor prognostic factors.To find the correlation between the factors and prognosis,a large sample of clinical research is needed.
