中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
12期
4-6
,共3页
前列腺癌%筛选%前列腺特异性抗原
前列腺癌%篩選%前列腺特異性抗原
전렬선암%사선%전렬선특이성항원
Prostate cancer%Screening%Prostate-specific angtigen
目的 通过对经筛查前列腺特异性抗原(PSA)发现和临床诊断发现的前列腺癌患者的临床和病理特征进行比较,评估PSA筛检在早期前列腺癌诊断中的作用.方法 自2011年7月至2012年10月,共有5632例≥50岁的男子参与了测量体内PSA的筛查,血清中PSA≥4.0 ng/ml的筛检者建议其行经直肠超声波扫描指导下的前列腺针吸活组织检查,把同一时期临床诊断为前列腺癌的82例患者作为对照组,评估分析筛查出和临床诊断为前列腺癌的临床和病理特征.结果 参加筛查的患者中共有473例(8.4％)PSA水平≥4.0 ng/ml,194例进行了病理活组织检查,38例患者诊断为前列腺癌.活检率、阳性预测值和发现率分别是41.0％、19.6％和0.7％.与临床诊断出的患者比较,筛检出的前列腺癌患者PSA ＜20 ng/ml(55.2％ vs 22.4％,P＜0.01),格里森评分＜7(60.3％ vs 34.1％,P＜0.01),病变局限于前列腺内(87.9％vs 26.8％,P＜0.01),具有根治性前列腺切除术的机会更多.结论 PSA对发现老年早期前列腺癌患者至关重要.评估PSA筛查在前列腺癌治疗结果和病死率中的意义,需要更进一步的研究.
目的 通過對經篩查前列腺特異性抗原(PSA)髮現和臨床診斷髮現的前列腺癌患者的臨床和病理特徵進行比較,評估PSA篩檢在早期前列腺癌診斷中的作用.方法 自2011年7月至2012年10月,共有5632例≥50歲的男子參與瞭測量體內PSA的篩查,血清中PSA≥4.0 ng/ml的篩檢者建議其行經直腸超聲波掃描指導下的前列腺針吸活組織檢查,把同一時期臨床診斷為前列腺癌的82例患者作為對照組,評估分析篩查齣和臨床診斷為前列腺癌的臨床和病理特徵.結果 參加篩查的患者中共有473例(8.4％)PSA水平≥4.0 ng/ml,194例進行瞭病理活組織檢查,38例患者診斷為前列腺癌.活檢率、暘性預測值和髮現率分彆是41.0％、19.6％和0.7％.與臨床診斷齣的患者比較,篩檢齣的前列腺癌患者PSA ＜20 ng/ml(55.2％ vs 22.4％,P＜0.01),格裏森評分＜7(60.3％ vs 34.1％,P＜0.01),病變跼限于前列腺內(87.9％vs 26.8％,P＜0.01),具有根治性前列腺切除術的機會更多.結論 PSA對髮現老年早期前列腺癌患者至關重要.評估PSA篩查在前列腺癌治療結果和病死率中的意義,需要更進一步的研究.
목적 통과대경사사전렬선특이성항원(PSA)발현화림상진단발현적전렬선암환자적림상화병리특정진행비교,평고PSA사검재조기전렬선암진단중적작용.방법 자2011년7월지2012년10월,공유5632례≥50세적남자삼여료측량체내PSA적사사,혈청중PSA≥4.0 ng/ml적사검자건의기행경직장초성파소묘지도하적전렬선침흡활조직검사,파동일시기림상진단위전렬선암적82례환자작위대조조,평고분석사사출화림상진단위전렬선암적림상화병리특정.결과 삼가사사적환자중공유473례(8.4％)PSA수평≥4.0 ng/ml,194례진행료병리활조직검사,38례환자진단위전렬선암.활검솔、양성예측치화발현솔분별시41.0％、19.6％화0.7％.여림상진단출적환자비교,사검출적전렬선암환자PSA ＜20 ng/ml(55.2％ vs 22.4％,P＜0.01),격리삼평분＜7(60.3％ vs 34.1％,P＜0.01),병변국한우전렬선내(87.9％vs 26.8％,P＜0.01),구유근치성전렬선절제술적궤회경다.결론 PSA대발현노년조기전렬선암환자지관중요.평고PSA사사재전렬선암치료결과화병사솔중적의의,수요경진일보적연구.
Objective Compare of the clinical and pathological features of patients with prostate cancer through screening prostate-specific antigen (PSA) and clinical diagnosis,to assess the role of PSA screening in the early diagnosis of prostate cancer.Methods From July 2011 to October 2012,a total of 5632 cases of ≥ 50 year old man was involved in the measurement of PSA screening.Serum PSA ≥4.0 ng/ml in patients who proposed its transrectal ultrasound scans under the guidance of the prostate needle aspiration biopsy.The same period,clinical diagnosis of 82 patients with prostate cancer as a control group,to assess the clinical and pathological features of patients with prostate cancer through screening and clinical diagnosis.Results A total of 473 patients(8.4％) participate in the screening PSA level ≥ 4.0 ng/ml,pathological biopsy was performed in 194 cases,38 cases of patients diagnosed as prostate cancer.Biopsy rate,positive predictive value and the detection rate was respectively 41.0％,19.6％ and 0.7％.Compared with prostate cancer patients according to clinical diagnosis,screening of prostate cancer in patients with PSA ＜20 ng/ml (55.2％ vs 22.4％,P ＜ 0.01),Gleason score ＜7 (60.3 vs 34.1％,P ＜ 0.01),lesions confined to the prostate (87.9％ vs 26.8％,P ＜0.01),had more radical prostatectomy (50.0％ vs 18.3％) opportunities.Conclusions PSA screening is essential in early diagnosis of prostate cancer.Assess significance of PSA screening for prostate cancer treatment outcomes and mortality,further study to be need.
