中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
14期
52-54
,共3页
王杰书%任鹏%李波%郝青%李洪林%王峰
王傑書%任鵬%李波%郝青%李洪林%王峰
왕걸서%임붕%리파%학청%리홍림%왕봉
I-TAC%CXCR3%结肠癌%肝转移
I-TAC%CXCR3%結腸癌%肝轉移
I-TAC%CXCR3%결장암%간전이
I-TAC%CXCR3%Colon carcinoma%Hepatic metastasis
目的 探讨I-TAC及其受体CXCR3在结肠癌组织中的表达及其临床意义.方法 免疫组织化学染色检测22例结肠癌肝转移手术标本和20例结肠癌无肝转移手术标本I-TAC及CXCR3表达,并分析与临床病理特征的关系.结果 I-TAC在肝转移组结肠癌组织中阳性表达率为86.36％,无肝转移组结肠癌组织中阳性表达率为45.00％,两组比较差异有统计学意义(P=0.005).CXCR3在肝转移组结肠癌组织中阳性表达率为72.72％,无肝转移组结肠癌组织中阳性表达率为35.00％,两组比较差异有统计学意义(P=0.014).相关性分析表明,I-TAC及其受体CXCR3的表达与结肠癌分化程度、淋巴结转移、肝转移呈正相关.结论 I-TAC及其受体CXCR3在肝转移组结肠癌组织中高表达,I-TAC和CXCR3表达与结肠癌肝转移有关.
目的 探討I-TAC及其受體CXCR3在結腸癌組織中的錶達及其臨床意義.方法 免疫組織化學染色檢測22例結腸癌肝轉移手術標本和20例結腸癌無肝轉移手術標本I-TAC及CXCR3錶達,併分析與臨床病理特徵的關繫.結果 I-TAC在肝轉移組結腸癌組織中暘性錶達率為86.36％,無肝轉移組結腸癌組織中暘性錶達率為45.00％,兩組比較差異有統計學意義(P=0.005).CXCR3在肝轉移組結腸癌組織中暘性錶達率為72.72％,無肝轉移組結腸癌組織中暘性錶達率為35.00％,兩組比較差異有統計學意義(P=0.014).相關性分析錶明,I-TAC及其受體CXCR3的錶達與結腸癌分化程度、淋巴結轉移、肝轉移呈正相關.結論 I-TAC及其受體CXCR3在肝轉移組結腸癌組織中高錶達,I-TAC和CXCR3錶達與結腸癌肝轉移有關.
목적 탐토I-TAC급기수체CXCR3재결장암조직중적표체급기림상의의.방법 면역조직화학염색검측22례결장암간전이수술표본화20례결장암무간전이수술표본I-TAC급CXCR3표체,병분석여림상병리특정적관계.결과 I-TAC재간전이조결장암조직중양성표체솔위86.36％,무간전이조결장암조직중양성표체솔위45.00％,량조비교차이유통계학의의(P=0.005).CXCR3재간전이조결장암조직중양성표체솔위72.72％,무간전이조결장암조직중양성표체솔위35.00％,량조비교차이유통계학의의(P=0.014).상관성분석표명,I-TAC급기수체CXCR3적표체여결장암분화정도、림파결전이、간전이정정상관.결론 I-TAC급기수체CXCR3재간전이조결장암조직중고표체,I-TAC화CXCR3표체여결장암간전이유관.
Objective To investigate the expression of I-TAC and its receptor CXCR3 in colon carcinoma and its clinical significance.Methods The expression of I-TAC and CXCR3 were detected by immunohistochemical staining in surgical specimens of colonic carcinoma with(22 cases) and without(20 cases) hepatic metastasis.Relationship between the above two indicators and clinicopathological characteristics were finally analyzed.Results Positive expression rate of I-TAC in the colonic tissue of colonic carcinoma with hepatic metastasis was 86.36％,while positive expression rate of I-TAC in the colonic tissue of colonic carcinoma without hepatic metastasis was 45.00％,there was significantly difference between the two groups(P =0.005).Positive expression rate of CXCR3 in the colonic tissue of colonic carcinoma with hepatic metastasis was 72.72％,while the positive expression rate of CXCR3 in the colonic tissue of coIonic carcinoma without hepatic metastasis was 35.00％,there was significantly difference between the two groups(P =0.014).Expression of I-TAC and CXCR3 in the tissue of colonic carcinoma were positively related to tissue histologic differentiation,lymph node metastasis and hepatic metastasis.Conclusions I-TAC and CXCR3 are highly expressed in the colonic tissue of colonic carcinomas with hepatic metastasis,which is related to the hepatic metastasis of colonic carcinoma.
