中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
15期
4-6
,共3页
魏平%李慧%谭静%宋景贵%李六一
魏平%李慧%譚靜%宋景貴%李六一
위평%리혜%담정%송경귀%리륙일
卒中后抑郁%重复经颅磁刺激%氟西汀%神经功能
卒中後抑鬱%重複經顱磁刺激%氟西汀%神經功能
졸중후억욱%중복경로자자격%불서정%신경공능
Post-stroke depression%repetitive transcranial magnetic stimulation%Fluoxetine%Neurological function
目的 探讨重复经颅磁刺激(rTMS)联合氟西汀治疗对卒中后抑郁(PSD)患者的抑郁情绪及神经功能的影响,为PSD患者的临床诊治和康复提供更多的有效手段.方法 将82例PSD患者分为研究组和对照组,两组在神经科常规治疗的基础上,研究组给予rTMS联合氟西汀治疗,对照组仅给予氟西汀治疗,采用汉密顿抑郁量表(HAMD)测评患者PSD患者的抑郁程度,采用爱丁堡-斯堪的纳维亚卒中量表(MESSS)和巴氏指数(BI)评定神经功能.结果 治疗8周后,研究组和对照组HAMD分值较治疗前明显下降(P＜0.01),且研究组较对照组HAMD分值下降更明显(P＜0.01).与治疗前相比,治疗8周后两组MESSS分值均降低、BI分值明显增加,差异有统计学意义(P＜0.01)；且研究组MESSS分值减低、BI测定分值较对照组升高更显著,差异有统计学意义(P＜0.01).结论 rTMS联合氟西汀治疗对PSD的抑郁情绪及神经功能的改善优于单纯的抗抑郁药物治疗.
目的 探討重複經顱磁刺激(rTMS)聯閤氟西汀治療對卒中後抑鬱(PSD)患者的抑鬱情緒及神經功能的影響,為PSD患者的臨床診治和康複提供更多的有效手段.方法 將82例PSD患者分為研究組和對照組,兩組在神經科常規治療的基礎上,研究組給予rTMS聯閤氟西汀治療,對照組僅給予氟西汀治療,採用漢密頓抑鬱量錶(HAMD)測評患者PSD患者的抑鬱程度,採用愛丁堡-斯堪的納維亞卒中量錶(MESSS)和巴氏指數(BI)評定神經功能.結果 治療8週後,研究組和對照組HAMD分值較治療前明顯下降(P＜0.01),且研究組較對照組HAMD分值下降更明顯(P＜0.01).與治療前相比,治療8週後兩組MESSS分值均降低、BI分值明顯增加,差異有統計學意義(P＜0.01)；且研究組MESSS分值減低、BI測定分值較對照組升高更顯著,差異有統計學意義(P＜0.01).結論 rTMS聯閤氟西汀治療對PSD的抑鬱情緒及神經功能的改善優于單純的抗抑鬱藥物治療.
목적 탐토중복경로자자격(rTMS)연합불서정치료대졸중후억욱(PSD)환자적억욱정서급신경공능적영향,위PSD환자적림상진치화강복제공경다적유효수단.방법 장82례PSD환자분위연구조화대조조,량조재신경과상규치료적기출상,연구조급여rTMS연합불서정치료,대조조부급여불서정치료,채용한밀돈억욱량표(HAMD)측평환자PSD환자적억욱정도,채용애정보-사감적납유아졸중량표(MESSS)화파씨지수(BI)평정신경공능.결과 치료8주후,연구조화대조조HAMD분치교치료전명현하강(P＜0.01),차연구조교대조조HAMD분치하강경명현(P＜0.01).여치료전상비,치료8주후량조MESSS분치균강저、BI분치명현증가,차이유통계학의의(P＜0.01)；차연구조MESSS분치감저、BI측정분치교대조조승고경현저,차이유통계학의의(P＜0.01).결론 rTMS연합불서정치료대PSD적억욱정서급신경공능적개선우우단순적항억욱약물치료.
Objective To investigate the effects of repeatitive transcranial magnetic stimulation (rTMS) and fluoxetine on depression and neurological function in the treatment of post-stroke depression (PSD) patients,to provide effective measures of clinical diagnosis and recovery.Methods All of 82 PSD patients were divided into the study group and the control group,besides of conventional neurological therapy,the study group was treated with rTMS combined with fluoxetine,while the control group only treated with fluoxetine.Hamilton Depression Rating Scale (HAMD) was used to evaluate depression emotion,Edinburgh-Scandinavia Stroke Scale(MESSS) and activity of daily living scale(ADL) were used to evaluate neurological function.Results After 8 weeks treatment,the scores of HAMD in the two groups were decreased significantly.And the scores of HAMD in the study group were decreased more significantly than that in the control group(P ＜0.01).After 8 weeks treatment,the scores of MESSS and ADL in the two groups were significant lower and higher respectively compared with before treatment (P ＜0.01),and the scores in the study group changed more obviously than that in the control group (P ＜ 0.01).Conclusions rTMS combined with fluoxetine can improve the depression and neurological function,and it' s better than antidepressant treatment only.
