中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
15期
12-14
,共3页
子痫前期%尿激酶型纤溶酶原激活因子%转化生长因子-β1%胎盘
子癇前期%尿激酶型纖溶酶原激活因子%轉化生長因子-β1%胎盤
자간전기%뇨격매형섬용매원격활인자%전화생장인자-β1%태반
Preeclampsia%Urokinase type plasminogen activator%Transforming growth factor-beta1%Placenta
目的 探讨子痫前期患者胎盘尿激酶型纤溶酶原激活因子(UPA)和转化生长因子-β1(TGF-β1)含量的变化及其在子痫前期发病中的意义.方法 采用酶联免疫吸附法测定57例子痫前期患者(子痫前期组,其中轻度患者24例,重度患者33例)和30例正常晚孕妇女(对照组)胎盘UPA和TGF-β1含量.结果 对照组胎盘UPA含量为(32.62±2.85) ng/g,子痫前期组为(11.42±4.67) ng/g,两组比较差异有统计学意义(P＜0.01)；且重度组[(8.11 ±4.25)ng/g]明显低于轻度组[(15.83±3.07) ng/g],差异有统计学意义(P＜0.01).对照组胎盘TGF-β1含量为(0.83±0.21)ng/g,子痫前期组为(1.12±0.37)ng/g,两组比较差异有统计学意义(P＜0.05)；重度子痫前期组为(1.33±0.35) ng/g,显著高于对照组(P＜0.05)；轻、重度组之间比较差异无统计学意义(P＞0.05).子痫前期患者胎盘UPA和TGF-β1含量呈负相关(r=-0.652,P＜0.01).结论 子痫前期患者胎盘UPA含量异常下降、TGF-β1含量异常升高与其发病及严重程度有关.
目的 探討子癇前期患者胎盤尿激酶型纖溶酶原激活因子(UPA)和轉化生長因子-β1(TGF-β1)含量的變化及其在子癇前期髮病中的意義.方法 採用酶聯免疫吸附法測定57例子癇前期患者(子癇前期組,其中輕度患者24例,重度患者33例)和30例正常晚孕婦女(對照組)胎盤UPA和TGF-β1含量.結果 對照組胎盤UPA含量為(32.62±2.85) ng/g,子癇前期組為(11.42±4.67) ng/g,兩組比較差異有統計學意義(P＜0.01)；且重度組[(8.11 ±4.25)ng/g]明顯低于輕度組[(15.83±3.07) ng/g],差異有統計學意義(P＜0.01).對照組胎盤TGF-β1含量為(0.83±0.21)ng/g,子癇前期組為(1.12±0.37)ng/g,兩組比較差異有統計學意義(P＜0.05)；重度子癇前期組為(1.33±0.35) ng/g,顯著高于對照組(P＜0.05)；輕、重度組之間比較差異無統計學意義(P＞0.05).子癇前期患者胎盤UPA和TGF-β1含量呈負相關(r=-0.652,P＜0.01).結論 子癇前期患者胎盤UPA含量異常下降、TGF-β1含量異常升高與其髮病及嚴重程度有關.
목적 탐토자간전기환자태반뇨격매형섬용매원격활인자(UPA)화전화생장인자-β1(TGF-β1)함량적변화급기재자간전기발병중적의의.방법 채용매련면역흡부법측정57례자간전기환자(자간전기조,기중경도환자24례,중도환자33례)화30례정상만잉부녀(대조조)태반UPA화TGF-β1함량.결과 대조조태반UPA함량위(32.62±2.85) ng/g,자간전기조위(11.42±4.67) ng/g,량조비교차이유통계학의의(P＜0.01)；차중도조[(8.11 ±4.25)ng/g]명현저우경도조[(15.83±3.07) ng/g],차이유통계학의의(P＜0.01).대조조태반TGF-β1함량위(0.83±0.21)ng/g,자간전기조위(1.12±0.37)ng/g,량조비교차이유통계학의의(P＜0.05)；중도자간전기조위(1.33±0.35) ng/g,현저고우대조조(P＜0.05)；경、중도조지간비교차이무통계학의의(P＞0.05).자간전기환자태반UPA화TGF-β1함량정부상관(r=-0.652,P＜0.01).결론 자간전기환자태반UPA함량이상하강、TGF-β1함량이상승고여기발병급엄중정도유관.
Objective To investigate the changes and significance of UPA and TGF-β1 in the etiology of preeclampsia(PE).Methods The levels of UPA and TGF-β1 were determined in 57 patients with PE.The data were compared with those of normal pregnant group (n =30).The levels of UPA and TGF-β1 in placenta tissue extraction were measured by means of enzyme linked immunosorbent assay (ELISA).Results The level of UPA in placenta in PE group [(11.42 ± 4.67)ng/g] was lower than that in normal pregnant group[(32.62 ±2.85)ng/g] (P ＜0.01).The level of UPA in severe PE group [(8.11 ± 4.25)ng/g] was lower than that in mild PE group [(15.83 ± 3.07)ng/g] (P ＜ 0.01).The level of TGF-β1 in placenta of PE group[(1.12 ±0.37) ng/g] was higher than that of normal pregnant group[(0.83 ±0.21)ng/g] (P ＜0.05).There was no significant difference in the levels of TGF-β1 between the severe PE group [(1.33 ± 0.35) ng/g] and the mild PE group [(0.91 ± 0.41) ng/g] (P ＞0.05).There was a negative correlation between the concentrations of UPA and TGF-β1 in placenta in PE(r =-0.652,P ＜0.01).Conclusions The changes of UPA and TGF-β1 are related to the occurrence and development of PE.
