CAJ | 학술논문

目的探讨微柱凝胶技术直接抗人球蛋白试验对同种免疫性溶血病的可行性及发病原因的分析.方法采用微柱凝胶技术对1681例新生儿高胆红素血症患儿做直接抗人球蛋白试验.结果本研究1681例新生儿高胆红素血症患儿微柱凝胶技术直接抗人球蛋白试验阳性497例,阳性率为29.6％；ABO血型系统所致的同种免疫性溶血病491例,占98.8％ (491/497),Rh血型系统所致的同种免疫性溶血病6例,占1.2％ (6/497).ABO血型系统中母亲O型,婴儿为A或B型476例,占96.9％ (476/491),母/婴血型为A/B等其他配型15例,占3.1％(15/491).结论直接抗人球蛋白试验与临床诊断符合率达90％以上,为新生儿溶血病提供实验室可靠诊断依据.
목적 탐토미주응효기술직접항인구단백시험대동충면역성용혈병적가행성급발병원인적분석.방법 채용미주응효기술대1681례신생인고담홍소혈증환인주직접항인구단백시험.결과 본연구1681례신생인고담홍소혈증환인미주응효기술직접항인구단백시험양성497례,양성솔위29.6％；ABO혈형계통소치적동충면역성용혈병491례,점98.8％ (491/497),Rh혈형계통소치적동충면역성용혈병6례,점1.2％ (6/497).ABO혈형계통중모친O형,영인위A혹B형476례,점96.9％ (476/491),모/영혈형위A/B등기타배형15례,점3.1％(15/491).결론 직접항인구단백시험여림상진단부합솔체90％이상,위신생인용혈병제공실험실가고진단의거.
Objective To investigate the feasibility of microcolumn gel technology direct antiglobulin test in the autoimmune hemolytic disease,and to analyze the causes of autoimmune hemolytic disease.Methods One thousand six hundred and eighty-one cases of neonatal hyperbilirubinemia children taken the direct antiglobulin test by microcolumn gel technology.Results Among the 1681 cases of neonatal hyperbilirubinemi children,with microcolumn gel direct antiglobulin test positive in 497 cases,the positive rate was 29.6％ ; with autoimmune hemolytic disease due to ABO blood group system 491 cases,accounting for 98.8％ (491/497) ; six cases of autoimmune hemolytic disease due to Rh blood group system,accounting for 1.2％ (6/497).O-ABO blood group system in the mother,the infant was type A or B of 476 cases,accounting for 96.9％ (476/491) ; The mother/infant blood group A/B,matching a total of 15 cases,accounting for 3.1％ (15/491).Conclusions The accordance rate of direct antiglobulin test and clinical diagnosis was 90％ or more,and direct antiglobulin test can provide reliable laboratory diagnostic basis for hemolytic disease of newboms.