中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
15期
65-68
,共4页
环氧化酶-2%Survivin%甲状腺乳头状癌%免疫组织化学%预后
環氧化酶-2%Survivin%甲狀腺乳頭狀癌%免疫組織化學%預後
배양화매-2%Survivin%갑상선유두상암%면역조직화학%예후
COX-2%Survivin%Papillary thyroid carcinoma%Immunohistochemistry%Prognosis
目的 检测甲状腺乳头状癌组织中环氧化酶-2 (COx-2)、Survivin的表达并探讨其临床意义.方法 回顾性分析2006年12月至2011年12月枣庄市立医院普外科手术治疗的60例甲状腺乳头状癌患者的临床病理学资料.采用免疫组织化学SP法检测癌组织及20例癌旁正常甲状腺组织石蜡切片中的COX-2和Survivin的表达.结果 甲状腺乳头状癌组织中COX-2和Survivin的阳性表达率分别为85.0％和66.7％,COX-2、Survivin在甲状腺乳头状癌组织中的阳性率均显著高于正常甲状腺组织；甲状腺乳头状癌组织中COX-2、Survivin的阳性表达强度与年龄、肿瘤大小无关(P＞0.05),其与临床分期、淋巴结转移相关,差异有统计学意义(P＜0.05).COX-2、Survivin阳性表达随着TNM分期增高而增强、淋巴结转移数目增加.甲状腺乳头状癌组织中COX-2、Survivin表达的呈正相关(r =0.396,P=0.004).COX-2和Survivin双阳性患者复发转移率高于双阴性患者(x2=4.181,P=0.041),COX-2和Survivin双阳性患者复发转移率高.结论 联合检测COX-2和Survivin的表达将有助于判断甲状腺乳头状癌的转移潜能及预后.
目的 檢測甲狀腺乳頭狀癌組織中環氧化酶-2 (COx-2)、Survivin的錶達併探討其臨床意義.方法 迴顧性分析2006年12月至2011年12月棘莊市立醫院普外科手術治療的60例甲狀腺乳頭狀癌患者的臨床病理學資料.採用免疫組織化學SP法檢測癌組織及20例癌徬正常甲狀腺組織石蠟切片中的COX-2和Survivin的錶達.結果 甲狀腺乳頭狀癌組織中COX-2和Survivin的暘性錶達率分彆為85.0％和66.7％,COX-2、Survivin在甲狀腺乳頭狀癌組織中的暘性率均顯著高于正常甲狀腺組織；甲狀腺乳頭狀癌組織中COX-2、Survivin的暘性錶達彊度與年齡、腫瘤大小無關(P＞0.05),其與臨床分期、淋巴結轉移相關,差異有統計學意義(P＜0.05).COX-2、Survivin暘性錶達隨著TNM分期增高而增彊、淋巴結轉移數目增加.甲狀腺乳頭狀癌組織中COX-2、Survivin錶達的呈正相關(r =0.396,P=0.004).COX-2和Survivin雙暘性患者複髮轉移率高于雙陰性患者(x2=4.181,P=0.041),COX-2和Survivin雙暘性患者複髮轉移率高.結論 聯閤檢測COX-2和Survivin的錶達將有助于判斷甲狀腺乳頭狀癌的轉移潛能及預後.
목적 검측갑상선유두상암조직중배양화매-2 (COx-2)、Survivin적표체병탐토기림상의의.방법 회고성분석2006년12월지2011년12월조장시립의원보외과수술치료적60례갑상선유두상암환자적림상병이학자료.채용면역조직화학SP법검측암조직급20례암방정상갑상선조직석사절편중적COX-2화Survivin적표체.결과 갑상선유두상암조직중COX-2화Survivin적양성표체솔분별위85.0％화66.7％,COX-2、Survivin재갑상선유두상암조직중적양성솔균현저고우정상갑상선조직；갑상선유두상암조직중COX-2、Survivin적양성표체강도여년령、종류대소무관(P＞0.05),기여림상분기、림파결전이상관,차이유통계학의의(P＜0.05).COX-2、Survivin양성표체수착TNM분기증고이증강、림파결전이수목증가.갑상선유두상암조직중COX-2、Survivin표체적정정상관(r =0.396,P=0.004).COX-2화Survivin쌍양성환자복발전이솔고우쌍음성환자(x2=4.181,P=0.041),COX-2화Survivin쌍양성환자복발전이솔고.결론 연합검측COX-2화Survivin적표체장유조우판단갑상선유두상암적전이잠능급예후.
Objective To investigate the expression of cyclooxygenase-2 (COX-2) and survivin in papillary thyroid carcinoma tissues and their clinical significance.Methods The clinical pathological data of 60 patients with papillary thyroid carcinoma managed with a routine surgical treatment in Zaozhuang municipal hospital from December 2006 to December 2011 were retrospectively analyzed.Immunohistochemical SP method was used to determine the expressions of COX-2 and survivin in the thyroid carcinoma tissues and 20 cases of adjacent normal thyroid tissues.Results The positive expression rates of COX-2 and survivin in the thyroid carcinoma tissues were 85.0％ and 66.7％,the positive expression rates of COX-2 and survivin in the thyroid carcinoma tissues were significantly higher than those in normal thyroid tissues.The positive expression rates of COX-2 and survivin in the thyroid carcinoma tissues were not related with age and tumor size (P ＞ 0.05),but were associated with clinical stage and the number of lymph node metastasis (P ＜ 0.05).The positive expressions of COX-2 and survivin in the thyroid carcinoma tissues were increased with the increase in TNM staging and the number of lymph node metastasis.COX-2 was positively correlated with survivin (r =0.396,P =0.004).COX-2 and survivin dualpositive patients had higher rates of recurrence and metastasis than COX-2 and survivin dual-negative patients(x2 =4.181,P =0.041),COX-2 and survivin double-positive patients with a high rate of recurrence and metastasis.Conclusions Detection of the expressions of COX-2 and survivin can estimate the metastatic potential and predict the prognosis for papillary thyroid carcinoma.
