CAJ | 학술논문

目的从临床角度分析N末端B型利钠肽原(NT-proBNP)水平与APACHEⅡ评分在慢性阻塞性肺疾病(COPD)需机械通气患者的内在关系.方法随机选择COPD患者83例,根据氧疗方法分为有创通气组(27例)、无创通气组(22例)和常规吸氧组(34例)进行分析.结果三组肺心病发病率比较差异有统计学意义(有创通气组63.0％,无创通气组31.8％,常规吸氧组14.7％,x2=15.545,P＜0.01).经方差分析及q检验(Newman-Keuls法),三组影响左心功能的基础疾病计分,NT-proBNP水平及APACHEⅡ评分差异均有统计学意义(P＜0.05或＜ 0.01).NT-proBNP水平与APACHEⅡ评分呈正相关(r=0.638,P＜0.01).结论 NT-proBNP综合反映了多种因素对COPD需机械通气患者心肺功能和病情的影响,与APACHEⅡ评分呈高度正相关.
목적 종림상각도분석N말단B형리납태원(NT-proBNP)수평여APACHEⅡ평분재만성조새성폐질병(COPD)수궤계통기환자적내재관계.방법 수궤선택COPD환자83례,근거양료방법분위유창통기조(27례)、무창통기조(22례)화상규흡양조(34례)진행분석.결과 삼조폐심병발병솔비교차이유통계학의의(유창통기조63.0％,무창통기조31.8％,상규흡양조14.7％,x2=15.545,P＜0.01).경방차분석급q검험(Newman-Keuls법),삼조영향좌심공능적기출질병계분,NT-proBNP수평급APACHEⅡ평분차이균유통계학의의(P＜0.05혹＜ 0.01).NT-proBNP수평여APACHEⅡ평분정정상관(r=0.638,P＜0.01).결론 NT-proBNP종합반영료다충인소대COPD수궤계통기환자심폐공능화병정적영향,여APACHEⅡ평분정고도정상관.
Objective To analyse the intrinsic relationship between NT-proBNP levels and APACHE Ⅱ score in patients with chronic obstructive pulmonary disease (COPD) requiring mechanical ventilated from the clinical point.Methods The data of 83 patients with COPD were analyzed and they were divided into invasive ventilation group (27 cases),non-invasive ventilation group (22 cases),conventional oxygen group (34 cases) according to the oxygen therapy.Results The pulmonary heart disease incidence rate had significant difference among the 3 groups(invasive ventilation group was 63％,non-invasive ventilation group was 31.8％,conventional oxygen group was 14.7％,x2 =15.545,P ＜0.01).The results of variance analysis and Q test (Newman-Keuls method):left cardiac function based disease score,NT-proBNP level and APACHE Ⅱ score were statistically significant among the 3 groups (P ＜ 0.05 or ＜0.01).The level of NT-proBNP and APACHE Ⅱ score showed a high positive correlationship (r =0.638,P ＜ 0.01).Conclusions NT-proBNP reflects the variety of factors in patients with the illness and the cardiopulmonary function effects of COPD requiring mechanical ventilation and were highly postively correlated with the APACHE Ⅱ score.