中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
16期
35-37
,共3页
梁家银%张守贞%赵海英%张勇
樑傢銀%張守貞%趙海英%張勇
량가은%장수정%조해영%장용
外周血嗜酸性粒细胞%肺结核%药物性肝损伤%预测
外週血嗜痠性粒細胞%肺結覈%藥物性肝損傷%預測
외주혈기산성립세포%폐결핵%약물성간손상%예측
Blood eosinophilic granulocyte%Lung tuberculosis%Drug-induced liver damage%Prediction
目的 探讨肺结核患者应用抗结核药物治疗后外周血嗜酸性粒细胞水平与肝损伤的关系.方法 选择2011年12月至2012年8月王开传染病医院住院的初治肺结核患者,在抗结核药物治疗前、治疗2、4、8周分别检查外周血嗜性粒细胞和肝功能,对嗜酸性粒细胞水平与肝功能异常进行相关性分析.结果 发生肝功能异常30例,占全部患者的27.03％ (30/111),肝功能异常出现时间6～47 c,平均(16±9)d,中位天数15 d,肝损伤发生率为8.11％(9/111)；治疗后肝功能异常组患者外周血嗜酸性粒细胞增高10例,占全部肝功能异常患者的33.33％(10/30),肝功能正常组患者外周血嗜酸性粒细胞增高13例,占全部肝功能正常患者的16.05％(13/81),两组比较差异有统计学意义(P＜0.05)；嗜酸性粒细胞增高天数与肝功能异常出现天数基本一致(P＞0.05)；外周血嗜酸性粒细胞增高与肝功能异常的相关性分析呈正线性相关(Pearson相关系数为0.189,P=0.047).结论 外周血嗜酸性粒细胞水平检测对抗结核药物引起的肝损伤,特别是非剂量依赖性肝损伤有一定的预测价值.
目的 探討肺結覈患者應用抗結覈藥物治療後外週血嗜痠性粒細胞水平與肝損傷的關繫.方法 選擇2011年12月至2012年8月王開傳染病醫院住院的初治肺結覈患者,在抗結覈藥物治療前、治療2、4、8週分彆檢查外週血嗜性粒細胞和肝功能,對嗜痠性粒細胞水平與肝功能異常進行相關性分析.結果 髮生肝功能異常30例,佔全部患者的27.03％ (30/111),肝功能異常齣現時間6～47 c,平均(16±9)d,中位天數15 d,肝損傷髮生率為8.11％(9/111)；治療後肝功能異常組患者外週血嗜痠性粒細胞增高10例,佔全部肝功能異常患者的33.33％(10/30),肝功能正常組患者外週血嗜痠性粒細胞增高13例,佔全部肝功能正常患者的16.05％(13/81),兩組比較差異有統計學意義(P＜0.05)；嗜痠性粒細胞增高天數與肝功能異常齣現天數基本一緻(P＞0.05)；外週血嗜痠性粒細胞增高與肝功能異常的相關性分析呈正線性相關(Pearson相關繫數為0.189,P=0.047).結論 外週血嗜痠性粒細胞水平檢測對抗結覈藥物引起的肝損傷,特彆是非劑量依賴性肝損傷有一定的預測價值.
목적 탐토폐결핵환자응용항결핵약물치료후외주혈기산성립세포수평여간손상적관계.방법 선택2011년12월지2012년8월왕개전염병의원주원적초치폐결핵환자,재항결핵약물치료전、치료2、4、8주분별검사외주혈기성립세포화간공능,대기산성립세포수평여간공능이상진행상관성분석.결과 발생간공능이상30례,점전부환자적27.03％ (30/111),간공능이상출현시간6～47 c,평균(16±9)d,중위천수15 d,간손상발생솔위8.11％(9/111)；치료후간공능이상조환자외주혈기산성립세포증고10례,점전부간공능이상환자적33.33％(10/30),간공능정상조환자외주혈기산성립세포증고13례,점전부간공능정상환자적16.05％(13/81),량조비교차이유통계학의의(P＜0.05)；기산성립세포증고천수여간공능이상출현천수기본일치(P＞0.05)；외주혈기산성립세포증고여간공능이상적상관성분석정정선성상관(Pearson상관계수위0.189,P=0.047).결론 외주혈기산성립세포수평검측대항결핵약물인기적간손상,특별시비제량의뢰성간손상유일정적예측개치.
Objective To investigate the correlation of anti-TB drugs with liver function damage via the blood eosinophilic granulocyte levels in patients with lung tuberculosis.Methods The primary treated tuberculosis patients in our hospital from December 2011 to August 2012 were involved.The blood eosinophilic granulocyte level and liver function were exarained at before anti-TB treatment and at 2 weeks,4 weeks,and 8 weeks later during the treatment.Thee correlation between blood eosinophilic granulocytes level and liver function were analyzed.Results Totally 30 patients were detected with abnormal liver functions after anti-TB treatment,the occurrence rate was 27.03％ (30/111).The abnormal liver functions last days was varied from 6 to 47 (16.23-±9.27)d,the median last day was 15,the liver function damage rate was 8.11％ (9/111).Ten of the 30 (the occurrence rate was 33.33％) abnormal liver functions patients were detected with increased peripheral blood eosinophilic granulocyte,but only 13 (the occurrence rate was 16.05％) in the normal liver function patients.The difference between the two groups was statistically significant (P ＜ 0.05),the sustained days was no difference between eosinophilic granulocyte increase and abnormal liver functions (P ＞ 0.05).It had a positive linear correlation between eosinophilic granulocyte increase and abnormal liver functions,the Pearson correlation coefficient was 0.189,P =0.047.Conclusions The blood eosinophilic granulocyte level was helpful to predict anti-TB drugs induced liver function damage in some degrees,especially in non-dose-dependent liver damage.
