中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
16期
47-49
,共3页
孟鲁司特%丙酸氟替卡松%毛细支气管炎%气道炎症%干预%疗效
孟魯司特%丙痠氟替卡鬆%毛細支氣管炎%氣道炎癥%榦預%療效
맹로사특%병산불체잡송%모세지기관염%기도염증%간예%료효
Montelukast%Fluticasone propionate%Bronchiolitis%Airway inflammation%Intervention%Curative effect
目的 探讨孟鲁司特联合丙酸氟替卡松对毛细支气管炎后气道炎症的干预作用及临床疗效.方法 100例毛细支气管炎患儿随机分为干预组和对照组.入院后给予常规治疗并测IL-4、INF-γ 、ECP和LTE4.病情控制后,干预组给予孟鲁司特钠4 mg,每晚1次,和丙酸氟替卡松1喷,每天1次,疗程为3个月.对照组不予任何干预治疗.疗程结束后(对照组病情控制3个月后)复查各指标.并随访1年,观察各组患儿3个月内喘息再次发作例数和1年内喘息发作≥3次例数.结果 干预组和对照组干预后IL-4、ECP、LTE4水平和IL-4/IFN-γ均较干预前显著降低,而INF-γ较干预前显著升高(P＜0.05或0.01),且干预组较对照组指标变化更为显著(P＜0.05或0.01).干预组患儿3个月内喘息再次发作例数和1年内喘息发作≥3次例数均较对照组患儿显著减少(P＜0.05).结论 孟鲁司特联合丙酸氟替卡松可有效控制毛细支气管炎后气道炎症,减少喘息发作.
目的 探討孟魯司特聯閤丙痠氟替卡鬆對毛細支氣管炎後氣道炎癥的榦預作用及臨床療效.方法 100例毛細支氣管炎患兒隨機分為榦預組和對照組.入院後給予常規治療併測IL-4、INF-γ 、ECP和LTE4.病情控製後,榦預組給予孟魯司特鈉4 mg,每晚1次,和丙痠氟替卡鬆1噴,每天1次,療程為3箇月.對照組不予任何榦預治療.療程結束後(對照組病情控製3箇月後)複查各指標.併隨訪1年,觀察各組患兒3箇月內喘息再次髮作例數和1年內喘息髮作≥3次例數.結果 榦預組和對照組榦預後IL-4、ECP、LTE4水平和IL-4/IFN-γ均較榦預前顯著降低,而INF-γ較榦預前顯著升高(P＜0.05或0.01),且榦預組較對照組指標變化更為顯著(P＜0.05或0.01).榦預組患兒3箇月內喘息再次髮作例數和1年內喘息髮作≥3次例數均較對照組患兒顯著減少(P＜0.05).結論 孟魯司特聯閤丙痠氟替卡鬆可有效控製毛細支氣管炎後氣道炎癥,減少喘息髮作.
목적 탐토맹로사특연합병산불체잡송대모세지기관염후기도염증적간예작용급림상료효.방법 100례모세지기관염환인수궤분위간예조화대조조.입원후급여상규치료병측IL-4、INF-γ 、ECP화LTE4.병정공제후,간예조급여맹로사특납4 mg,매만1차,화병산불체잡송1분,매천1차,료정위3개월.대조조불여임하간예치료.료정결속후(대조조병정공제3개월후)복사각지표.병수방1년,관찰각조환인3개월내천식재차발작례수화1년내천식발작≥3차례수.결과 간예조화대조조간예후IL-4、ECP、LTE4수평화IL-4/IFN-γ균교간예전현저강저,이INF-γ교간예전현저승고(P＜0.05혹0.01),차간예조교대조조지표변화경위현저(P＜0.05혹0.01).간예조환인3개월내천식재차발작례수화1년내천식발작≥3차례수균교대조조환인현저감소(P＜0.05).결론 맹로사특연합병산불체잡송가유효공제모세지기관염후기도염증,감소천식발작.
Objective To investigate the intervention and the curative effect of montelukast combined with fluticasone propionate in the treatment of airway inflammation for post-bronchiolitis.Methods One hundred children with bronchiolitis were randomly divided irto the intervention group and the control group.All patients were given conventional therapy and deterrmined the level of IL-4,INF-γ,ECP,LTE4 after hospitalization.When the conditions were stable,the intervention group were treated with montelukast 4 mg qn and fluticasone propionate 1 spray qd for 3 months.The control group were not given any treatment.The level of [L-4,INF-γ,ECP,LTE4 were reexamine after 3 months.To count the cases of recurrence of asthma within 3 months and recurrence more than 3 times one year by follow-up for one year.Results The level of IL-4,ECP,LTE4 and IL-4/IFN-γwere significantly lower in the two groups after intervention than before,and thelevel of IFN-γ were higher (P ＜ 0.05 or 0.01).The level of IL-4,IgE,EOS and IL-4/IFN-γ were higher in the intervention group than that of control group and level of IFN-γwere lower after treatment (P ＜ 0.05 or 0.01).The recurrence cases of asthma within 3 months and recurrence more than 3 times one year in the intervention group were significantly reduced than control group (P ＜ 0.05).Conclusions Montelukast combined with fluticasone propionate can effectively control airway inflammation for post-bronchiolitis and reduce asthma attacks times.
