CAJ | 학술논문

目的探讨Smo及Gli1蛋白在食管鳞状细胞癌组织中的表达及其意义.方法采用免疫组织化学方法检测68例食管鳞癌、35例癌旁不典型增生和68例正常食管黏膜组织中Smo及Gli1的蛋白表达,并分析其与食管鳞状细胞癌临床病理学参数间的关系.结果在正常食管黏膜、癌旁不典型增生及食管鳞状细胞癌组织中Smo蛋白的阳性表达率依次增高,分别为0％(0/38)、28.6％(10/35)和69.1％ (47/68),组间两两比较差异有统计学意义(P ＜0.05)；Gli1蛋白的阳性表达率在正常食管黏膜、癌旁不典型增生及食管鳞癌组织中亦依次增高,分别为2.6％(1/38)、34.3％(12/35)和73.5％(50/68),组间比较差异有统计学意义(P ＜0.05)；Smo与Gli1的阳性表达率均与食管鳞状细胞癌组织学分级、浸润深度、淋巴结转移及TNM分期密切相关(P均＜0.05).结论 Smo及Gli1蛋白表达升高可能与食管鳞状细胞癌的发生、发展及浸润转移相关.
목적 탐토Smo급Gli1단백재식관린상세포암조직중적표체급기의의.방법 채용면역조직화학방법검측68례식관린암、35례암방불전형증생화68례정상식관점막조직중Smo급Gli1적단백표체,병분석기여식관린상세포암림상병이학삼수간적관계.결과 재정상식관점막、암방불전형증생급식관린상세포암조직중Smo단백적양성표체솔의차증고,분별위0％(0/38)、28.6％(10/35)화69.1％ (47/68),조간량량비교차이유통계학의의(P ＜0.05)；Gli1단백적양성표체솔재정상식관점막、암방불전형증생급식관린암조직중역의차증고,분별위2.6％(1/38)、34.3％(12/35)화73.5％(50/68),조간비교차이유통계학의의(P ＜0.05)；Smo여Gli1적양성표체솔균여식관린상세포암조직학분급、침윤심도、림파결전이급TNM분기밀절상관(P균＜0.05).결론 Smo급Gli1단백표체승고가능여식관린상세포암적발생、발전급침윤전이상관.
Objective To investigate the expressions and clinical significance of Smo protein and Gli1 protein in esophageal squamous cell carcinoma (ESCC).Methods The expressions of Smo protein and Gli1 protein in 68 cases of ESCC tissue,35 cases of adjacent atypical hyperplasia tissue,and 68 cases of normal esophageal mucosa tissue were detected by immunohistochemistry methods,and its relationships with clinicopathological parameters of ESCC were analyzed.Results The positive expression rates of Smo protein in normal esophageal epithelium specimens,adjacent atypical hyperplasia epithelium and ESCC tissue were 0％ (0/38),28.6％ (10/35),69.1％ (47/68),respectively.There were significant differences between the groups (P ＜0.05).The positive expression rates of Gli1 protein in normal esophageal epithelium specimens,adjacent atypical hyperplasia epithelium and ESCC tissue were 2.6％ (1/38),34.3％ (12/35),73.5％ (50/68),respectively.There were significant differences between the groups (P ＜ 0.05).The positive expression rates of Smo and Gli1 mRNA were closely related to the histological grade,infiltrative depth,lymphatic node metastasis and TNM grade in ESCC (P ＜ 0.05).Conclusions The increased expression levels of Smo and Gli1 protein may be related to the genesis,development,invasion and metastasis of ESCC.