CAJ | 학술논문

目的检测结核性脑膜炎患儿脑脊液中白细胞介素-17 (IL-17)和金属基质蛋白酶-9(MMP-9)的水平,探讨其在结核性脑膜炎发病及诊断中的作用.方法将15例结核性脑膜炎(TBM)、20例病毒性脑炎(VM)及18例非中枢神经系统感染儿童,分列为TBM组、VM组和对照组.应用ELISA法测定3组儿童脑脊液中IL-17和MMP-9的水平.结果 TBM组脑脊液中IL-17和MMP-9水平明显升高,与其他两组相比较,差异均有统计学意义(P＜0.0l).结论 IL-17和MMP-9在结核性脑膜炎患儿脑脊液中均显著升高,提示它们可能参与了结核性脑膜炎的病理过程.检测脑炎患儿脑脊液中IL-17、MMP-9水平,有助于结核性脑膜炎与病毒性脑膜炎的临床鉴别.
목적 검측결핵성뇌막염환인뇌척액중백세포개소-17 (IL-17)화금속기질단백매-9(MMP-9)적수평,탐토기재결핵성뇌막염발병급진단중적작용.방법 장15례결핵성뇌막염(TBM)、20례병독성뇌염(VM)급18례비중추신경계통감염인동,분렬위TBM조、VM조화대조조.응용ELISA법측정3조인동뇌척액중IL-17화MMP-9적수평.결과 TBM조뇌척액중IL-17화MMP-9수평명현승고,여기타량조상비교,차이균유통계학의의(P＜0.0l).결론 IL-17화MMP-9재결핵성뇌막염환인뇌척액중균현저승고,제시타문가능삼여료결핵성뇌막염적병리과정.검측뇌염환인뇌척액중IL-17、MMP-9수평,유조우결핵성뇌막염여병독성뇌막염적림상감별.
Objective To detect the levels of IL-17 and MMP-9 in cerebrospinal fluid of children with tuberculous meningitis,and to study their role in the diagnosis of tuberculous meningitis.Methods The 15 cases of children with tuberculous meningitis (TBM),20 cases of children with viral encephalitis (VM) and 18 cases of children without central nervous system infections,were choosed as the TBM group,the VM group and the control group.The levels of IL-17 and MMP-9 in cerebrospinal fluid were detected by ELISA method.Results The levels of IL-17 and MMP-9 in cerebrospinal fluid in TBM group increased significantly.Compared with other two groups,respectively,the differences were significant (P ＜0.01).Conclusions The levels of IL-17 and MMP-9 in cerebrospinal fluid of patients with tuberculous meningitis were all highly increased,suggesting they might be involved in the pathological process of tuberculous meningitis.The levels of IL-17 and MMP-9 in cerebrospinal fluid can help identification of tuberculous meningitis with viral meningitis.