CAJ | 학술논문

目的研究阿托伐他汀对急性缺血性脑卒中患者血脂异常及血清C-反应蛋白(CRP)的影响.方法将76例急性缺血性脑卒中患者随机分为两组,研究组37例,对照组39例.研究组在常规治疗基础上加用阿托伐他汀20 mg,每日1次,连续服用14 d；对照组仅给予常规治疗.在治疗前后检测两组患者血脂水平及血清CRP,并进行神经功能缺损程度评分(NDS)评定.结果治疗14 d后两组血脂水平均较治疗前下降,且治疗组较对照组下降明显(P＜0.05),研究组总胆固醇及CRP水平均较对照组下降明显(P＜0.05)；两组NDS评分较治疗前明显下降(P＜0.05),且治疗组较对照组下降明显(P＜0.05).结论阿托伐他汀能明显降低急性缺血性脑卒中患者血脂及CRP水平,并有助于患者神经功能的恢复.
목적 연구아탁벌타정대급성결혈성뇌졸중환자혈지이상급혈청C-반응단백(CRP)적영향.방법 장76례급성결혈성뇌졸중환자수궤분위량조,연구조37례,대조조39례.연구조재상규치료기출상가용아탁벌타정20 mg,매일1차,련속복용14 d；대조조부급여상규치료.재치료전후검측량조환자혈지수평급혈청CRP,병진행신경공능결손정도평분(NDS)평정.결과 치료14 d후량조혈지수평균교치료전하강,차치료조교대조조하강명현(P＜0.05),연구조총담고순급CRP수평균교대조조하강명현(P＜0.05)；량조NDS평분교치료전명현하강(P＜0.05),차치료조교대조조하강명현(P＜0.05).결론 아탁벌타정능명현강저급성결혈성뇌졸중환자혈지급CRP수평,병유조우환자신경공능적회복.
Objective To study the effect of atorvastatin on dyslipidemia and serum C-reactive protein(CRP) in acute ischemic stroke patients.Methods Seventy-six patients with acute ischemic stroke were randomely divided into two groups,37 cases in atorvastatin group and 39 cases in control group.Patients in atorvastatin group were given atorvastatin 20 mg/d for 14 days on the basis of conventional therapy.Patients in control group were given conventional therapy.The changes of serum levels of CRP,dyslipidemia and NDS grade were measured before and after treatment.Results After 14 days of treatment,the content of dyslipidemia and C-reactive protein were significantly decreased (P ＜ 0.05),TC and C-reactive protein were significantly decreased in atorvastatin group than those in control group (P ＜ 0.05).NDS grade was decreased more significant in the atorvastatin group than that in the control group(P ＜ 0.05).Conclusions Atorvastatin could decrease the levels of dyslipidemia and C-reactive protein in acute ischemic stroke patients,and is helpful for recovery of the nervous function of patients.