CAJ | 학술논문

目的探讨胞二磷胆碱辅助治疗对帕金森病(PD)轻度认知功能障碍(PD-MCI)的作用,以及对PD-MCI患者血浆磷脂(PLs)含量的影响.方法收集2006年5月至2011年6月间参与帕金森病协作研究的85例PD患者的人口学资料,完成帕金森病统一评定量表第Ⅲ部分(UPDRS-Ⅲ)及蒙特利尔认知评估量表(MoCA)的评测.根据评测结果将PD-MCI分为治疗组和对照组,前者在基本药物治疗的基础上加用胞磷胆碱钠胶囊100 mg,3次/d口服,分别于治疗后12个月和18个月进行MoCA评测及PLs含量测定.血浆PLs测定采用层析技术结合改良的无机磷定量方法.结果 85例PD患者中41例(48.2％)存在PD-MCI.治疗后12、18个月,治疗组和对照组MoCA评分比较差异均有统计学意义(P＜0.05,P＜0.01)；治疗后12、18个月治疗组血浆PLs含量较对照组显著降低(P＜0.01).结论胞二磷胆碱辅助治疗可延缓PD-MCI患者认知功能下降速率,并能降低其血浆PLs含量,具有神经保护作用.
목적 탐토포이린담감보조치료대파금삼병(PD)경도인지공능장애(PD-MCI)적작용,이급대PD-MCI환자혈장린지(PLs)함량적영향.방법 수집2006년5월지2011년6월간삼여파금삼병협작연구적85례PD환자적인구학자료,완성파금삼병통일평정량표제Ⅲ부분(UPDRS-Ⅲ)급몽특리이인지평고량표(MoCA)적평측.근거평측결과장PD-MCI분위치료조화대조조,전자재기본약물치료적기출상가용포린담감납효낭100 mg,3차/d구복,분별우치료후12개월화18개월진행MoCA평측급PLs함량측정.혈장PLs측정채용층석기술결합개량적무궤린정량방법.결과 85례PD환자중41례(48.2％)존재PD-MCI.치료후12、18개월,치료조화대조조MoCA평분비교차이균유통계학의의(P＜0.05,P＜0.01)；치료후12、18개월치료조혈장PLs함량교대조조현저강저(P＜0.01).결론 포이린담감보조치료가연완PD-MCI환자인지공능하강속솔,병능강저기혈장PLs함량,구유신경보호작용.
Objective To investigate the effect of citicoline adjuvant therapy on mild cognitive impairment in Parkinson' s disease (PD) and the influence on plasma phospholipids (PLs) levels.Methotis Eighty-five PD patients were recruited and collected for the general information.The patients were evaluated by Unified Parkinson' s Disease Rating Scale (UPDRS) 11I and Montreal Cognitive Assessment (MoCA).According to MoCA scores,patients with PD-MCI were divided into citicoline treatment group (citicoline 100 rag,tid orally) and control group(basic L-dopa or dopamine agonist).Reevaluating cognitive function by MoCA and plasma phopholipids levels at posttreatment 12 months and 18 months.Plasma PLs was assayed by measuring its inorganic phosphorus after separation by chromatograph.Results Forty-one cases in 85 PD patients(48.2％) were combined with PD-MCI.After 12 months and 18 months treatment period,MoCA scores were significantly higher in citicoline treatment group than those in control group(P ＜ 0.05,P ＜ 0.01 respectively).Plasma PLs levels were significantly decreased in citicoline treatment group than those in control group (P ＜ 0.01).Conclusions Citicoline is effective on the adjuvant treatment of PD-MCI,and it could delay cognitive rate of decline in patients with PD.Meanwhile,Citicoline could decrease significantly plasma PLs levels in PD-MCI.Citicoline has neuroprotective effects on patients with PD-MCI.