CAJ | 학술논문

目的探讨血脂正常高血压2级患者应用阿托伐他汀治疗后对血管内皮功能的影响及意义.方法 116例血脂正常高血压2级患者,随机分为阿托伐他汀治疗组(58例)和对照组(58例),对照组给予常规治疗,治疗组在常规治疗基础上加用阿托伐他汀1o mg,每日1次,疗程共8周.分别于治疗前后测定血浆中一氧化氮(N0)和血管性假血友病因子(vWF)的水平.结果治疗组和对照组治疗前血浆中NO、vWF水平比较差异无统计学意义(JP＞0.05)；治疗8周后两组血浆中NO、vWF水平比较差异有统计学意义(P＜0.05).结论阿托伐他汀对血脂正常高血压2级患者血管内皮功能有保护作用,值得临床推广应用.
목적 탐토혈지정상고혈압2급환자응용아탁벌타정치료후대혈관내피공능적영향급의의.방법 116례혈지정상고혈압2급환자,수궤분위아탁벌타정치료조(58례)화대조조(58례),대조조급여상규치료,치료조재상규치료기출상가용아탁벌타정1o mg,매일1차,료정공8주.분별우치료전후측정혈장중일양화담(N0)화혈관성가혈우병인자(vWF)적수평.결과 치료조화대조조치료전혈장중NO、vWF수평비교차이무통계학의의(JP＞0.05)；치료8주후량조혈장중NO、vWF수평비교차이유통계학의의(P＜0.05).결론 아탁벌타정대혈지정상고혈압2급환자혈관내피공능유보호작용,치득림상추엄응용.
Objective To investigate the influence and significance of atorvastatin on endothelium dependent vasodilatation function in hypertensive patients without hyperlipemia.Methods One hundred and sixteen hypetensives without hyperlipemia were randomly divided into atorvastatin group (n =58) and control group(n =58).Patients in control group were treated by routine treatment,and patients in atorvastatin group were treated with atorvastatin 10 mg/d on the basis of the routine treatment,the course of treatment were 8 weeks.Nitric oxide(NO) and vascular false hemophilia factor (vWF) levels were measured before and after 8 weeks treatment.Results Before treatment,the plasma levels of NO and vWF had no statistically significant difference between the two groups(P ＞0.05) ; But after 8 weeks treatment,there were statistically significant differences of plasma levels of NO and vWF between the two groups (P ＜ 0.05).Conclusions Atorvastatin improves endothelial function in hypertensives without hyperlipemia,it has clinical application value.