CAJ | 학술논문

目的研究养血清脑颗粒在人体内对卡马西平(CBZ)药代动力学的影响.方法采用自身交叉试验方法,8名健康受试者禁食10 h后于清晨口服卡马西平200 mg,在不同的时间点采集血样.10 d后志愿者开始口服养血清脑颗粒,每天3次,每次4 9.在服用养血清脑颗粒后第7天清晨同时服用卡马西平片200 mg,按相同时间点再次采集血样.用高效液相色谱法检测血样中卡马西平的浓度.用Kinetica 5.0软件计算药代动力学参数.结果单用CBZ和CBZ与养血清脑颗粒同时应用时,CBZ的Cmax、Tmaxx、T1/2、AUC0-t、CL差异无统计学意义(P＞0.05).结论养血清脑颗粒不影响卡马西平的吸收和体内代谢过程.
목적 연구양혈청뇌과립재인체내대잡마서평(CBZ)약대동역학적영향.방법 채용자신교차시험방법,8명건강수시자금식10 h후우청신구복잡마서평200 mg,재불동적시간점채집혈양.10 d후지원자개시구복양혈청뇌과립,매천3차,매차4 9.재복용양혈청뇌과립후제7천청신동시복용잡마서평편200 mg,안상동시간점재차채집혈양.용고효액상색보법검측혈양중잡마서평적농도.용Kinetica 5.0연건계산약대동역학삼수.결과 단용CBZ화CBZ여양혈청뇌과립동시응용시,CBZ적Cmax、Tmaxx、T1/2、AUC0-t、CL차이무통계학의의(P＞0.05).결론 양혈청뇌과립불영향잡마서평적흡수화체내대사과정.
Objective To study the effect of yangxueqingnao particles on the pharmacokinetics of carbamazepine in healthy volunteers.Methods Eight subjects were oral administrated with carbamazepine (200 mg) in the morning after fasted ten hours.Blood samples were draw at different time.Yangxueqingnao particles were taken 10 days latter.When yangxueqingnao particles were taken 7 days,carbamazepine (200 mg) was oral given again.Blood was drew off at the same time again.High performance liquid chromatography was used to determine the concentration of carbamazepine.Kinetica 5.0 was used to calculate the pharmacokinetic parameters.Results There was no significant difference between the two groups in the pharmacokinetic parameters of carbamazepine,such as C T T1/2,AUC0-t,CL (P ＞ 0.05).Conclusions The yangxueqingnao particles have no effect on the absorption and metabolism of carbamazepine in human.