CAJ | 학술논문

目的研究C-erbB-2、雌激素受体(ER)、孕激素受体(PR)在子宫内膜腺癌的表达及临床意义.方法采用SP法对54例子宫内膜腺癌患者标本进行C-erbB-2、ER、PR的检测,分析其表达率及与临床分期、组织学分级、肌层浸润、淋巴结转移的关系.结果 C-erbb-2及ER、PR在子宫内膜腺癌中的阳性表达率分别为37.04％(20/54)、42.59％ (23/54)、51.85％ (28/54).C-erbB-2与组织学分级、肌层浸润程度、淋巴结转移相关(P＜0.05),尚不能认为与手术病理分期相关(P＞0.05);PR与组织学分级有关(P＜0.05),尚不能认为与其他各项相关;也尚不能认为ER与手术病理分期、组织学分级、肌层浸润及淋巴结转移相关.结论 C-erbB-2的表达与肿瘤的侵袭性有关,可能是评估子宫内膜癌预后的重要指标.PR在癌组织中检测为阳性,常预后良好,而ER与预后无关.
목적 연구C-erbB-2、자격소수체(ER)、잉격소수체(PR)재자궁내막선암적표체급림상의의.방법 채용SP법대54례자궁내막선암환자표본진행C-erbB-2、ER、PR적검측,분석기표체솔급여림상분기、조직학분급、기층침윤、림파결전이적관계.결과 C-erbb-2급ER、PR재자궁내막선암중적양성표체솔분별위37.04％(20/54)、42.59％ (23/54)、51.85％ (28/54).C-erbB-2여조직학분급、기층침윤정도、림파결전이상관(P＜0.05),상불능인위여수술병리분기상관(P＞0.05);PR여조직학분급유관(P＜0.05),상불능인위여기타각항상관;야상불능인위ER여수술병리분기、조직학분급、기층침윤급림파결전이상관.결론 C-erbB-2적표체여종류적침습성유관,가능시평고자궁내막암예후적중요지표.PR재암조직중검측위양성,상예후량호,이ER여예후무관.
Objective To investigate the expression and clinical significance of C-erbB-2,estrogen receptor(ER) and progesterone receptor(PR) in adenocarcinoma of endometrium.Methods The expressions of C-erbB-2,ER and PR in 54 patients with adenocarcinoma of endometrium were detected with SP immunohistochemical method.The relationship between expression rate and clinical stage,histological grade,myometrial invasion,lymph node metastasis was analyzed.Results The positive ratios of C-erbB-2,ER and PR were 37.04％ (20/54),42.59％ (23/54),51.85％ (28/54)respectively.The expression of C-erbB-2 was significant correlated with histological grade,myometrium invasion and lymphatic metastasis (P ＜ 0.05),but not with surgical stage (P ＞ 0.05) ; There was significant correlation of PR with histological grade ; No correlation was found of expressions of ER with clinical stage,histological grade,myometrial invasion or lymph node metastasis of adenocarcinoma of endometrium.Conclusions The expression of C-erbB-2 is associated with tumor invasion,and maybe a significant prognostic factor of adenocarcinoma of endometrium,positive PR may suggest a better prognosis,but ER has no significant prognostic relevance.