CAJ | 학술논문

目的评价血浆(1,3)-β-D葡聚糖测定(C试验)对慢性阻塞性肺疾病(COPD)合并侵袭性肺部真菌感染(IPrI)的诊断价值.方法检测98例有IPFI高危因素的COPD患者的G试验值,计算G试验的敏感度及特异度,比较真菌感染组患者与非真菌感染组(1,3)-β-D葡聚糖血浆浓度.结果以20 pg/ml为临界值,G试验在COPD并IFPI中的敏感度为81％,特异度为86％.真菌感染组患者血浆(1,3)-β-D葡聚糖浓度明显高于非真菌感染组,差异有统计学意义(P＜0.05).结论 G实验用于COPD合并IPFI诊断具有简便、快速、阳性率高的优点,并可作为早期诊断以弥补传统方法的不足.
목적 평개혈장(1,3)-β-D포취당측정(C시험)대만성조새성폐질병(COPD)합병침습성폐부진균감염(IPrI)적진단개치.방법 검측98례유IPFI고위인소적COPD환자적G시험치,계산G시험적민감도급특이도,비교진균감염조환자여비진균감염조(1,3)-β-D포취당혈장농도.결과 이20 pg/ml위림계치,G시험재COPD병IFPI중적민감도위81％,특이도위86％.진균감염조환자혈장(1,3)-β-D포취당농도명현고우비진균감염조,차이유통계학의의(P＜0.05).결론 G실험용우COPD합병IPFI진단구유간편、쾌속、양성솔고적우점,병가작위조기진단이미보전통방법적불족.
Objective To evaluate the diagnosis value of(1,3)-β-D-glucan antigens(G test)on patients with invasive pulmonary fungal infections(IPFI) complicated with chronic obstructive pulmonary disease(COPD).Methods The levels of(1,3)-β-D-glucan antigens in 98 high-risk of IPFI patients with COPD were detected.The sensitivity and specificity of G test was calculated.The(1,3)-β-D-glucan concentrations of fungal infection and non-fungal infection group were compared.Results At a cutoff 20 pg/ml,the sensitivity and specificity of G test for IPFI patients with COPD was 81％ and 86％.The (1,3)-β-D-glucan concentration of patients with fungal infection was significantly higher than that of patients with non-fungal infection (P ＜ 0.05).Conclusions (1,3)-β-D-glucan detection has the advantages of simple,rapid and high positive rate in diagnosis of IPFI patients with COPD.Meanwhile,G test can be used in early diagnosis for making up the deficiency of the traditional method.