CAJ | 학술논문

目的比较MEA(米托蒽醌、依托泊苷、阿糖胞苷)、HEA(高三尖杉酯碱、依托泊苷、阿糖胞苷)方案治疗成人难治性急性单核细胞白血病的疗效及安全性.方法选择郑州大学第一附属医院血液科确诊为难治性急性单核细胞白血病患者46例,其中26例应用MEA,20例应用HEA,观察两组的临床疗效及不良反应.结果 MEA方案组:26例患者中完全缓解(CR)17例(65.4％),部分缓解(PR)5例(19.2％),未缓解(NR)4例(15.4％);HEA方案组:20例患者CR 9例(45.0％),PR 3例(15.0％),NR 8例(40.0％).结论 MEA方案疗效较HEA方案好,可作为复发或难治性急性单核细胞白血病的优先考虑的化疗方案.
목적 비교MEA(미탁은곤、의탁박감、아당포감)、HEA(고삼첨삼지감、의탁박감、아당포감)방안치료성인난치성급성단핵세포백혈병적료효급안전성.방법 선택정주대학제일부속의원혈액과학진위난치성급성단핵세포백혈병환자46례,기중26례응용MEA,20례응용HEA,관찰량조적림상료효급불량반응.결과 MEA방안조:26례환자중완전완해(CR)17례(65.4％),부분완해(PR)5례(19.2％),미완해(NR)4례(15.4％);HEA방안조:20례환자CR 9례(45.0％),PR 3례(15.0％),NR 8례(40.0％).결론 MEA방안료효교HEA방안호,가작위복발혹난치성급성단핵세포백혈병적우선고필적화료방안.
Objective To compare the clinical efficiency and security of MEA (Mitoxantrone,Cytarabine,Etoposide)and HEA (Homoharringtonine,Cytarabine,Etoposide) protocols on acute monouclear leukemia.Methods Forty-six replapsed or refractory patients were enrolled in this study.Twentysix patients were administered with MEA and 20 patients were administered with HEA,and then the clinical curative effect and side effects of the two groups were observed.Results Clinical response of MEA regimen:17 out of 26 patients (65.4％) achieved complete remission (CR),5 cases (19.2％) achieved partial remission(PR),4 cases(15.4％) no response.Clinical response of HEA regimen:9 out of 20 patients(45％) achieved CR,5cases(19.2％) achieved PR,4 cases(15.4％) no response.Conclusions MEA solutions is more effective than HEA solutions,MEA regimen can be used as a recurrent or refractory acute mononuclear leukemia chemotherapy regimens of priority.