CAJ | 학술논문

目的研究对急性下肢深静脉血栓(DVT)形成患者采用导管溶栓术(CDT)治疗的可行性和疗效.方法对山西医学科学院山西大医院116例急性DVT患者采用CDT进行治疗,比较治疗前后健、患侧大腿和小腿周径差、通畅度评分的变化.结果所有患者均成功导入溶栓导管,且术后即刻下腔静脉造影结果呈现为滤器内通畅,血栓无明显脱落.患者CDT治疗时间2～7d,住院时间7～15 d,其中6例牙龈出血,4例皮下瘀青,2例患者术后穿刺处渗血(压迫止血,未曾出现肺动脉栓塞等并发症).溶栓后患、健侧大腿和小腿周径差明显小于溶栓前,静脉通畅改善率为(55±4)％,且治疗后通畅度评分显著高于治疗前,上述差异均有统计学意义(P＜0.05).结论 CDT治疗DVT临床操作简单,治疗效果明显,减少了溶栓药物用量且并发症少,因此可显著改善患者的生活质量,减少后遗症的发生.
목적 연구대급성하지심정맥혈전(DVT)형성환자채용도관용전술(CDT)치료적가행성화료효.방법 대산서의학과학원산서대의원116례급성DVT환자채용CDT진행치료,비교치료전후건、환측대퇴화소퇴주경차、통창도평분적변화.결과 소유환자균성공도입용전도관,차술후즉각하강정맥조영결과정현위려기내통창,혈전무명현탈락.환자CDT치료시간2～7d,주원시간7～15 d,기중6례아간출혈,4례피하어청,2례환자술후천자처삼혈(압박지혈,미증출현폐동맥전새등병발증).용전후환、건측대퇴화소퇴주경차명현소우용전전,정맥통창개선솔위(55±4)％,차치료후통창도평분현저고우치료전,상술차이균유통계학의의(P＜0.05).결론 CDT치료DVT림상조작간단,치료효과명현,감소료용전약물용량차병발증소,인차가현저개선환자적생활질량,감소후유증적발생.
Objective To study the feasiability and effect of catheter-directed thrombolysis (CDT) on lower limb acute deep venous thrombosis(CDT).Methods One hundred and sixteen patients with DVT underwent CDT treatment,and the circumference and venous patency score before and after the thrombolysis were compared between impaired thigh and healthy thigh and between impaired leg and healthy leg.Results The initial technical success rate of CDT treatment was 100％.The duration of CDT treatment was 2-7 d,hospitalization time was 7-15 d,with 6 cases of gums bleeding,4 cases of subcutaneous bruises and 2 cases of errhysis complications.The differences in circumference between impaired thigh and healthy thigh and between impaired leg and healthy leg after treatment were significantly smaller than those before treatment and the venous patency score after treatment were significantly larger than those before treatment(P ＜ O.05).The rate of patency improvement after treatment was(55 ± 4) ％.Conclusions Catheter-directed thrombolysis with urokinase for acute lower limb deep venous thrombosis is safe and effective and it can improve the life quality of patients,reduce the incidence of sequela.