中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
7期
1-3
,共3页
樊锐太%孙银银%王鑫%宋锐%吴竞%刘云
樊銳太%孫銀銀%王鑫%宋銳%吳競%劉雲
번예태%손은은%왕흠%송예%오경%류운
食管鳞癌%瞬时受体电位通道6%放疗%预后
食管鱗癌%瞬時受體電位通道6%放療%預後
식관린암%순시수체전위통도6%방료%예후
Esophageal squamous cell carcinoma%Transient receptor potential canonical type 6%Radiotherapy%Prognosis
目的 探讨瞬时受体电位通道6(TPRC6)在食管鳞癌中的表达水平以及TRPC6蛋白表达水平与食管鳞癌放疗预后的关系.方法 回顾性研究2008年至2011年于郑州大学第一附属医院行根治性放疗的86例食管鳞癌患者的临床资料,应用免疫组化法检测86例食管鳞癌组织标本中TRPC6的表达水平.Kaplan-Meier法计算生存率并用Log-rank法检验,Cox模型多因素预后分析.结果 TRPC6在食管鳞癌中的阳性表达主要在细胞膜及胞浆中,其中高表达率为47.7％ (41/86),低表达率为52.3％ (45/86).TRPC6蛋白表达水平与肿瘤是否复发与远处转移相关(P＜0.05).Cox多因素分析结果显示,TRPC6蛋白表达水平是预测食管鳞癌放疗预后的一个独立因素(x2=9.089,P=0.003).结论 TRPC6蛋白表达水平可作为评价食管鳞癌患者放疗预后的一个新的指标.
目的 探討瞬時受體電位通道6(TPRC6)在食管鱗癌中的錶達水平以及TRPC6蛋白錶達水平與食管鱗癌放療預後的關繫.方法 迴顧性研究2008年至2011年于鄭州大學第一附屬醫院行根治性放療的86例食管鱗癌患者的臨床資料,應用免疫組化法檢測86例食管鱗癌組織標本中TRPC6的錶達水平.Kaplan-Meier法計算生存率併用Log-rank法檢驗,Cox模型多因素預後分析.結果 TRPC6在食管鱗癌中的暘性錶達主要在細胞膜及胞漿中,其中高錶達率為47.7％ (41/86),低錶達率為52.3％ (45/86).TRPC6蛋白錶達水平與腫瘤是否複髮與遠處轉移相關(P＜0.05).Cox多因素分析結果顯示,TRPC6蛋白錶達水平是預測食管鱗癌放療預後的一箇獨立因素(x2=9.089,P=0.003).結論 TRPC6蛋白錶達水平可作為評價食管鱗癌患者放療預後的一箇新的指標.
목적 탐토순시수체전위통도6(TPRC6)재식관린암중적표체수평이급TRPC6단백표체수평여식관린암방료예후적관계.방법 회고성연구2008년지2011년우정주대학제일부속의원행근치성방료적86례식관린암환자적림상자료,응용면역조화법검측86례식관린암조직표본중TRPC6적표체수평.Kaplan-Meier법계산생존솔병용Log-rank법검험,Cox모형다인소예후분석.결과 TRPC6재식관린암중적양성표체주요재세포막급포장중,기중고표체솔위47.7％ (41/86),저표체솔위52.3％ (45/86).TRPC6단백표체수평여종류시부복발여원처전이상관(P＜0.05).Cox다인소분석결과현시,TRPC6단백표체수평시예측식관린암방료예후적일개독립인소(x2=9.089,P=0.003).결론 TRPC6단백표체수평가작위평개식관린암환자방료예후적일개신적지표.
Objective To investigate the expression levels of transient receptor potential canonical type 6 (TPRC6) in esophageal squamous cell carcinoma (ESCC),and the relationship between the protein expression levels of TRPC6 and the prognosis of patients with ESCC after radiotherapy.Methods From2008 to 2011,the clinical data of 86 patients with ESCC underwent radical radiotherapy in the first affiliated hospital of Zhengzhou university were retrospectively studied.Immunohistochemical SP method was used to measure the protein expression levels of TRPC6 in 86 ESCC tissue samples.The KaplanMeier method was used for calculating the survival rate and the Log-rank test was used for survival difference analysis.The Cox model was used for multivariate prognostic analysis.Results The positive expression of TRPC6 in ESCC was mainly observed in the cell membrane and cytoplasm.The high expression rate of TRPC6 was 47.7％ (41/86) and the low expression rate was 52.3％ (45/86).The protein expression level of TRPC6 was correlated with tumor recurrence and distant metastasis (P ＜ 0.05).The multivariate prognostic analysis showed that the protein expression level of TRPC6 was an independent factor for prediction of the prognosis of ESCC patients after radiotherapy(x2 =9.089,P =0.003).Conclusions The protein expression level of TRPC6 can be used as a new marker for evaluating the prognosis of ESCC patients after radiotherapy.
