中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
7期
22-23
,共2页
妊娠期高血压疾病%胎盘%缺氧诱导因子-1
妊娠期高血壓疾病%胎盤%缺氧誘導因子-1
임신기고혈압질병%태반%결양유도인자-1
Hypertensive disorder complicating pregnancy%Placenta%Hypoxia inducible factor-1
目的 探讨缺氧诱导因子-1(HIF-1)在胎盘中表达的升高及其所诱发的血管内皮损伤在妊娠期高血压疾病发病中的作用机制.方法 采用免疫组化法检测妊娠期高血压疾病患者和正常晚孕妇女胎盘组织中HIF-1和可溶性血管内皮生长因子受体-1(sFlt-1)的表达,放射免疫法检测母血中内皮素(ET-1)的含量.结果 妊娠期高血压疾病组胎盘中HIF-1和sFlt-1的表达以及母血ET-1水平均较正常晚孕组升高.结论 HIF-1在胎盘组织中表达的升高及其所诱发的血管内皮损伤在妊娠期高血压疾病发病中起重要作用.
目的 探討缺氧誘導因子-1(HIF-1)在胎盤中錶達的升高及其所誘髮的血管內皮損傷在妊娠期高血壓疾病髮病中的作用機製.方法 採用免疫組化法檢測妊娠期高血壓疾病患者和正常晚孕婦女胎盤組織中HIF-1和可溶性血管內皮生長因子受體-1(sFlt-1)的錶達,放射免疫法檢測母血中內皮素(ET-1)的含量.結果 妊娠期高血壓疾病組胎盤中HIF-1和sFlt-1的錶達以及母血ET-1水平均較正常晚孕組升高.結論 HIF-1在胎盤組織中錶達的升高及其所誘髮的血管內皮損傷在妊娠期高血壓疾病髮病中起重要作用.
목적 탐토결양유도인자-1(HIF-1)재태반중표체적승고급기소유발적혈관내피손상재임신기고혈압질병발병중적작용궤제.방법 채용면역조화법검측임신기고혈압질병환자화정상만잉부녀태반조직중HIF-1화가용성혈관내피생장인자수체-1(sFlt-1)적표체,방사면역법검측모혈중내피소(ET-1)적함량.결과 임신기고혈압질병조태반중HIF-1화sFlt-1적표체이급모혈ET-1수평균교정상만잉조승고.결론 HIF-1재태반조직중표체적승고급기소유발적혈관내피손상재임신기고혈압질병발병중기중요작용.
Objective To investigate the role of elevated HIF-1 levels in placenta and the vascular endothelial injury in the pathogenic mechanism of hypertensive disorder complicating pregnancy.Methods The levels of HIF-1 and sFlt-1 expression in placenta were detected by immunohistochemistry,and the maternal blood level of ET-1 was measured by radioimmunoassay.Results Compared with normal group,the levels of HIF-1 and sFlt-1 expression in placenta,the blood level of ET-1 in hypertensive disorder complicating pregnancy group all increased significantly.Conclusions The elevated HIF-1 expression levels in placenta and the induced vascular endothelial play aninjury important role in hypertensive disorder complicating pregnancy.
