CAJ | 학술논문

目的探讨缺血修饰白蛋白(IMA)在急性冠状动脉综合征患者经皮冠状动脉介入治疗(PCI)术后的变化和意义.方法选取35例择期PCI术的急性冠状动脉综合征患者为病例组,分别于术前,术后30 min、6h及24 h抽取肘静脉血,检测IMA水平、同时检测肌钙蛋白(cTnⅠ)、肌酸激酶同工酶(CK-MB)水平,并与40例健康者(对照组)进行比较.结果病例组IMA及cTnⅠ、CK-MB水平明显高于健康对照组,差异有统计学意义(P＜0.05);病例组术后30 min IMA水平即开始升高,6h逐渐降至基线水平,而cTnⅠ、CK-MB在术后6h才开始升高,24 h仍在高峰水平.结论 PCI术可致心肌一过性缺血损伤,IMA在术后迅速升高且早于cTnⅠ,IMA可作为诊断急性心肌缺血的敏感指标.
목적 탐토결혈수식백단백(IMA)재급성관상동맥종합정환자경피관상동맥개입치료(PCI)술후적변화화의의.방법 선취35례택기PCI술적급성관상동맥종합정환자위병례조,분별우술전,술후30 min、6h급24 h추취주정맥혈,검측IMA수평、동시검측기개단백(cTnⅠ)、기산격매동공매(CK-MB)수평,병여40례건강자(대조조)진행비교.결과 병례조IMA급cTnⅠ、CK-MB수평명현고우건강대조조,차이유통계학의의(P＜0.05);병례조술후30 min IMA수평즉개시승고,6h축점강지기선수평,이cTnⅠ、CK-MB재술후6h재개시승고,24 h잉재고봉수평.결론 PCI술가치심기일과성결혈손상,IMA재술후신속승고차조우cTnⅠ,IMA가작위진단급성심기결혈적민감지표.
Objective To investigate the changes and significant of ischemia modified albumin levels in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention.Methods Thirty-five patients with ACS,who had recieived percutaneous coronary intervention (PCI) treatment,were selected to measure the levels of IMA,cTnⅠ and CK-MB before and 30 min,6 h,24 h after PCI trentment respectively,and the results were compared with 40 cases of healthy controls.Results The level of IMA in patients with acute coronary syndrome was higher than that in healthy controls,and there was significant difference between them (P ＜ 0.05).IMA levels began to increase at 30 min after PCI treatment,and gradually decreased to baseline level after 6 h,while the levels of cTnⅠ,CK-MB began to rise after 6 h,still at peak level at 24 h after PCI.Conclusions PCI can cause light injuries of myocardium,the level of IMA increased rapidly and earlier than cTnⅠ after PCI ; IMA can be used as a sensitive index for the diagnosis of acute myocardial ischemia.