CAJ | 학술논문

目的探讨阿托伐他汀对中青年单纯高血压患者血管内皮细胞功能及血压的影响.方法将74例血压达标的中青年单纯高血压患者随机分为研究组和对照组,每组37例,对照组给予饮食控制加氨氯地平和美托洛尔降压治疗,研究组在此基础上加用阿托伐他汀.治疗8周后比较两组患者血压、血清一氧化氮浓度(NO)、肱动脉血流介导的血管扩张(FMD)、颈股动脉脉搏波速度(CFPWV)的变化.结果治疗后,两组患者血清NO、FMD均升高,CFPWV、血压均降低,与治疗前比较差异有统计学意义(P＜0.05),研究组与对照组比较差异有统计学意义(P＜0.05).结论阿托伐他汀可改善中青年单纯高血压患者血管内皮细胞功能,并有助于其血压的降低.
목적 탐토아탁벌타정대중청년단순고혈압환자혈관내피세포공능급혈압적영향.방법 장74례혈압체표적중청년단순고혈압환자수궤분위연구조화대조조,매조37례,대조조급여음식공제가안록지평화미탁락이강압치료,연구조재차기출상가용아탁벌타정.치료8주후비교량조환자혈압、혈청일양화담농도(NO)、굉동맥혈류개도적혈관확장(FMD)、경고동맥맥박파속도(CFPWV)적변화.결과 치료후,량조환자혈청NO、FMD균승고,CFPWV、혈압균강저,여치료전비교차이유통계학의의(P＜0.05),연구조여대조조비교차이유통계학의의(P＜0.05).결론 아탁벌타정가개선중청년단순고혈압환자혈관내피세포공능,병유조우기혈압적강저.
Objective To investigate the effect of atorvastatin on vascular endothelial function and blood pressure in young and middle-aged hypertensive patients without complications.Methods Seventy-four young and middle-aged hypertensive patients with blood pressure controlled well and without complications were randomly divided into study group (37 cases) and control group (37 cases).Patients in both groups received amlodipine,metoprolol treatment,and diet control.In addition,patients in study group also received 20 mg of atorvastatin.After 8 weeks' treatment,changes of blood pressure,serum nitric oxide (NO),flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity(CFPWV) in the two groups were compared.Results Compared with the test data before treatment,the values of NO and FMD significantly increased,and the values of blood pressure and CFPWV significantly decreased after treatment in both groups (P ＜ 0.05).Compared with the changes of control group,the changes of test indexes in study group were more significant(P ＜0.05).Conclusions Atorvastatin can improve the endothelial function and has certain antihypertensive effect for young and middle-aged hypertensive patients without complications,.