中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
7期
50-52
,共3页
分泌型卷曲相关蛋白4%2型糖尿病%糖脂代谢%胰岛功能
分泌型捲麯相關蛋白4%2型糖尿病%糖脂代謝%胰島功能
분비형권곡상관단백4%2형당뇨병%당지대사%이도공능
Secreted frizzled related protein 4 (SFRP4)%Type 2 diabetes mellitus%Glucose and lipid metabolism%Islet function
目的 探讨不同糖耐量人群血浆分泌型卷曲相关蛋白4(secreted frizzled-related protein 4,SFRP4)水平与糖脂代谢和胰岛功能的关系.方法 采用ELISA法测定60例糖尿病前期患者(pre-diabetes组)、80例初发2型糖尿病患者(T2DM组)及80例健康对照者(NC组)血浆SFRP4水平,用单因素方差分析法比较上述各组SFRP4水平,分析血浆SFRP4水平与相关代谢指标的关系,采用多元逐步回归法找出影响SFRP4水平的主要因素.结果 T2DM组血浆SFRP4水平均高于pre-diabetes组和NC组,且pre-diabetes组高于NC组(P均＜0.05);相关性研究显示SFRP4与糖化血红蛋白呈正相关(P＜0.01),而与空腹胰岛素(FIns)、胰岛素抵抗指数(HOMA-IR)呈负相关(P＜0.05);多元逐步回归分析显示HOMA-IR是影响血浆SFRP4水平的独立因素(β=-2.019,P＜0.05).结论 循环SFRP4在糖尿病前期、初发2型糖尿病患者中呈高表达,对预测T2DM的发生有重要意义.
目的 探討不同糖耐量人群血漿分泌型捲麯相關蛋白4(secreted frizzled-related protein 4,SFRP4)水平與糖脂代謝和胰島功能的關繫.方法 採用ELISA法測定60例糖尿病前期患者(pre-diabetes組)、80例初髮2型糖尿病患者(T2DM組)及80例健康對照者(NC組)血漿SFRP4水平,用單因素方差分析法比較上述各組SFRP4水平,分析血漿SFRP4水平與相關代謝指標的關繫,採用多元逐步迴歸法找齣影響SFRP4水平的主要因素.結果 T2DM組血漿SFRP4水平均高于pre-diabetes組和NC組,且pre-diabetes組高于NC組(P均＜0.05);相關性研究顯示SFRP4與糖化血紅蛋白呈正相關(P＜0.01),而與空腹胰島素(FIns)、胰島素牴抗指數(HOMA-IR)呈負相關(P＜0.05);多元逐步迴歸分析顯示HOMA-IR是影響血漿SFRP4水平的獨立因素(β=-2.019,P＜0.05).結論 循環SFRP4在糖尿病前期、初髮2型糖尿病患者中呈高錶達,對預測T2DM的髮生有重要意義.
목적 탐토불동당내량인군혈장분비형권곡상관단백4(secreted frizzled-related protein 4,SFRP4)수평여당지대사화이도공능적관계.방법 채용ELISA법측정60례당뇨병전기환자(pre-diabetes조)、80례초발2형당뇨병환자(T2DM조)급80례건강대조자(NC조)혈장SFRP4수평,용단인소방차분석법비교상술각조SFRP4수평,분석혈장SFRP4수평여상관대사지표적관계,채용다원축보회귀법조출영향SFRP4수평적주요인소.결과 T2DM조혈장SFRP4수평균고우pre-diabetes조화NC조,차pre-diabetes조고우NC조(P균＜0.05);상관성연구현시SFRP4여당화혈홍단백정정상관(P＜0.01),이여공복이도소(FIns)、이도소저항지수(HOMA-IR)정부상관(P＜0.05);다원축보회귀분석현시HOMA-IR시영향혈장SFRP4수평적독립인소(β=-2.019,P＜0.05).결론 순배SFRP4재당뇨병전기、초발2형당뇨병환자중정고표체,대예측T2DM적발생유중요의의.
Objective To investigate the correlation of plasma levels of secreted frizzled related protein 4 with glucose and lipid metabolism and islet function in people with different glucose tolerance.Methods The plasma SFRP4 levels of 60 patients in pre-diabetes mellitus group,80 patients with newly diagnosed type 2 diabetes mellitus (T2DM group) and 80 cases in normal control group were detected by ELISA method.Single factor analysis of variance method was used to compare the SFRP4 levels.The correlation of plasma SFRP4 levels with related metabolic indexes was analyzed.Multiple stepwise regression method was used to find out the main factors influencing the expression levels of SFRP4.Results The plasma levels of SFRP4 in T2DM group were higher than those in pre-diabetes group and NC group,and those in pre-diabetes group were higher than those in NC group (P ＜ 0.05) ; Correlation study showed that the SFRP4 level was positively correlated with the level of HbA1c(P ＜ 0.01),and was negatively correlated with FIns and HOMA-IR (P ＜ 0.05) ; Multiple stepwise regression analysis showed that HOMA-IR was the independent factor influencing the plasma level of SFRP4 (β =-2.019,P ＜ 0.05).Conclusions The plasma SFRP4 level is highly expressed in pre-diabetes patients and newly diagnosed type 2 diabetes patients.It has important value in predicting the occurrence of T2DM.
