CAJ | 학술논문

目的通过检测肝硬化患者血清血管内皮生长因子(VEGF)的变化,从而研究VEGF在肝硬化及合并上消化道出血发病机制中的作用.方法采用酶联免疫吸附法(ELISA)测定50例肝硬化组和30例对照组血清中血管内皮生长因子的含量.结果 Child-PughA级、B级患者血清VEGF的含量明显高于对照组和Child-Pugh C级肝硬化患者(P＜0.05);Child-Pugh A级患者血清VEGF的含量高于Child-Pugh B级肝硬化患者,差异有统计学意义(P＜0.05).肝硬化并发上消化道出血患者血VEGF高于无上消化道出血者,差异有统计学意义(P＜0.05).结论血清VEGF含量和肝硬化肝功能损伤程度及上消化道出血有关,可作为判断肝硬化的预后,预测上消化道出血发生的一种血清学指标.
목적 통과검측간경화환자혈청혈관내피생장인자(VEGF)적변화,종이연구VEGF재간경화급합병상소화도출혈발병궤제중적작용.방법 채용매련면역흡부법(ELISA)측정50례간경화조화30례대조조혈청중혈관내피생장인자적함량.결과 Child-PughA급、B급환자혈청VEGF적함량명현고우대조조화Child-Pugh C급간경화환자(P＜0.05);Child-Pugh A급환자혈청VEGF적함량고우Child-Pugh B급간경화환자,차이유통계학의의(P＜0.05).간경화병발상소화도출혈환자혈VEGF고우무상소화도출혈자,차이유통계학의의(P＜0.05).결론 혈청VEGF함량화간경화간공능손상정도급상소화도출혈유관,가작위판단간경화적예후,예측상소화도출혈발생적일충혈청학지표.
Objective By detecting the changes of serum vascular endothelial growth factor (VEGF) in patients with cirrhosis,to study the effect of VEGF on the pathogenesis of cirrhosis and upper gastrointestinal bleeding.Methods Determination of 50 cases of cirrhosis group and 30 cases of control group.The levels of serum vascular endothelial growth factor in 50 patients with cirrhosis and 30 patients in control group were detected by enzyme-linked immunosorbent (ELISA).Results The serum VEGF levels in patients with Child-Pugh A level and B level were significantly higher than those in the control group and patients with Child-Pugh C level; The serum VEGF levels in patients with Child-Pugh A level was higher than that in patients with Child-Pugh B level,there were significant differences (P ＜ 0.05).The serum VEGF level in patients with cirrhosis complicated with upper gastrointestinal hemorrhage was higher than that in patients without gastrointestinal bleeding,the difference was significant (P ＜ 0.05).Conclusions The serum VEGF level is associated with the degree of liver dysfunction and the upper gastrointestinal bleeding,it can be used as a serological indicators of judging the prognosis of cirrhosis and predicting upper gastrointestinal bleeding.