中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
9期
23-26
,共4页
奈达铂%奥沙利铂%卡铂%紫杉烷%妇科肿瘤%不良反应
奈達鉑%奧沙利鉑%卡鉑%紫杉烷%婦科腫瘤%不良反應
내체박%오사리박%잡박%자삼완%부과종류%불량반응
Nedaplatin%Oxaliplatin%Carboplatin%Taxane%Gynecological tumor%Toxicity
目的 比较奈达铂、奥沙利铂以及卡铂与紫杉烷化疗对临床妇科肿瘤毒性反应的影响.方法 2012年2月至2013年3月南阳医学高等专科学校第一附属医院共136例妇科患者确诊为晚期或复发型肿瘤.以数字法随机分成奈达铂联合治疗组(44例)、奥沙利铂联合治疗组(45例)、卡铂联合治疗组(47例),并实施对应治疗,比较三组临床疗效以及不良反应.结果 奈达铂联合组总有效率为59.09％(26/44),奥沙利铂联合组为51.11％(23/45),卡铂联合组为55.32％(26/47).三组两两比较差异均无统计学意义(P均＞0.05).奈达铂联合组血小板减少的发生率为46.8％(51/109),显著高于奥沙利铂联合组的32.1％ (36/112)和卡铂联合组的26.8％(30/112)、神经感觉性异常的发生率为12.8％(14/109),发热的发生率为0,均显著低于奥沙利铂联合组的24.1％(27/112),8.9％(10/112);而奥沙利铂联合组中性粒细胞下降的发生率为74.3％(81/109),显著低于卡铂联合组的83.8％ (94/112);神经感觉性异常的发生率为24.1％(27/112),显著高于卡铂联合组的11.6％(13/112).差异均有统计学意义(P均＜0.05).结论 奈达铂、奥沙利铂以及卡铂三种铂类治疗恶性妇科肿瘤,奈达铂疗效稍高,但三组不良反应各有差异,临床可视情况酌情选择.
目的 比較奈達鉑、奧沙利鉑以及卡鉑與紫杉烷化療對臨床婦科腫瘤毒性反應的影響.方法 2012年2月至2013年3月南暘醫學高等專科學校第一附屬醫院共136例婦科患者確診為晚期或複髮型腫瘤.以數字法隨機分成奈達鉑聯閤治療組(44例)、奧沙利鉑聯閤治療組(45例)、卡鉑聯閤治療組(47例),併實施對應治療,比較三組臨床療效以及不良反應.結果 奈達鉑聯閤組總有效率為59.09％(26/44),奧沙利鉑聯閤組為51.11％(23/45),卡鉑聯閤組為55.32％(26/47).三組兩兩比較差異均無統計學意義(P均＞0.05).奈達鉑聯閤組血小闆減少的髮生率為46.8％(51/109),顯著高于奧沙利鉑聯閤組的32.1％ (36/112)和卡鉑聯閤組的26.8％(30/112)、神經感覺性異常的髮生率為12.8％(14/109),髮熱的髮生率為0,均顯著低于奧沙利鉑聯閤組的24.1％(27/112),8.9％(10/112);而奧沙利鉑聯閤組中性粒細胞下降的髮生率為74.3％(81/109),顯著低于卡鉑聯閤組的83.8％ (94/112);神經感覺性異常的髮生率為24.1％(27/112),顯著高于卡鉑聯閤組的11.6％(13/112).差異均有統計學意義(P均＜0.05).結論 奈達鉑、奧沙利鉑以及卡鉑三種鉑類治療噁性婦科腫瘤,奈達鉑療效稍高,但三組不良反應各有差異,臨床可視情況酌情選擇.
목적 비교내체박、오사리박이급잡박여자삼완화료대림상부과종류독성반응적영향.방법 2012년2월지2013년3월남양의학고등전과학교제일부속의원공136례부과환자학진위만기혹복발형종류.이수자법수궤분성내체박연합치료조(44례)、오사리박연합치료조(45례)、잡박연합치료조(47례),병실시대응치료,비교삼조림상료효이급불량반응.결과 내체박연합조총유효솔위59.09％(26/44),오사리박연합조위51.11％(23/45),잡박연합조위55.32％(26/47).삼조량량비교차이균무통계학의의(P균＞0.05).내체박연합조혈소판감소적발생솔위46.8％(51/109),현저고우오사리박연합조적32.1％ (36/112)화잡박연합조적26.8％(30/112)、신경감각성이상적발생솔위12.8％(14/109),발열적발생솔위0,균현저저우오사리박연합조적24.1％(27/112),8.9％(10/112);이오사리박연합조중성립세포하강적발생솔위74.3％(81/109),현저저우잡박연합조적83.8％ (94/112);신경감각성이상적발생솔위24.1％(27/112),현저고우잡박연합조적11.6％(13/112).차이균유통계학의의(P균＜0.05).결론 내체박、오사리박이급잡박삼충박류치료악성부과종류,내체박료효초고,단삼조불량반응각유차이,림상가시정황작정선택.
Objective To compare the effects of nedaplatin,oxaliplatin and carboplatin combined with taxane chemotherapy on clinical gynecologic tumor cytotoxicity reaction.Methods From February 2012 to March 2013,in the first affiliated hospital of Nanyang medical college,a total of 136 gynecological patients with advanced or recurrent type tumors were chose.They were randomly divided into the nedaplatin group (44 cases),oxaliplatin group (45 cases),carboplatin group (47 cases),and were treated with corresponding treatment,the clinical efficacy and toxicity reaction were compared.Results The total effective rate in nedaplatin group was 59.09％ (26/44),in oxaliplatin group was 51.11％ (23/45),in carboplatin group was 55.32％ (26/47),compared with each other,the differences were not statistically significant(P ＞0.05).The incidence of thrombocytopenia in iedaplatin group was 46.8％ (51/109),which was higher than that in oxaliplatin group (32.1％,36/112) and that in carboplatin group(26.8％,30/112) ; The incidence of nerve sensory abnormalities was 12.8％ (14/109),the incidence of fever was 0,which were lower than those in oxaliplatin group (24.1％,27/112),(8.9％,10/112); and the incidence of neutropenia in oxaliplatin group was 74.3％ (81/109),which was lower than that in the carboplatin group (83.8％,94/112); The incidence of nerve sensory abnormalities was 24.1％ (27/112),which was higher than that in carboplatin group(11.6％,13/112).There were significant differences (P all ＜ 0.05).Conclusions In the treatment of malignant gynecological tumors with nedaplatin and oxaliplatin,carboplatin(three kinds of platinum),the nedaplatin has higher efficacy,but there are significant differences in toxicity,and the clinically appropriate choice should be made according to the circumstances.
