中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
9期
34-36
,共3页
化疗%肿瘤%结肠癌%奥沙利铂%卡培他滨
化療%腫瘤%結腸癌%奧沙利鉑%卡培他濱
화료%종류%결장암%오사리박%잡배타빈
Chemotherapy%Tumor%Colon cancer%Oxaliplatin%Capecitabine
目的 比较卡培他滨联合奥沙利铂与奥沙利铂单独治疗晚期结肠癌的疗效.方法 将130例晚期结肠癌患者随机分为观察组和对照组,每组65例.观察组采取卡培他滨联合奥沙利铂治疗,对照组使用奥沙利铂单独治疗.观察两组治疗后的疗效、治疗前后卡式功能状态评分、生存时间、1.5年病死率和不良反应情况,以评价两种治疗方法的效果.结果 观察组完全缓解、部分缓解、稳定、恶化患者分别有9、22、26和8例,治疗总有效率为47.69％,疾病控制率为87.69％,相比于对照组的29.23％和67.69％,差异有统计学意义(P＜0.05).观察组生存时间明显长于对照组,1.5年病死率显著低于对照组(P＜0.05).两组治疗前后KPS功能评分和不良反应发生率比较差异无统计学意义(P＞0.05).结论 相比于单独使用奥沙利铂,卡培他滨联合奥沙利铂治疗晚期结肠癌可以显著提升疗效,改善患者预后,值得在临床中推广使用.
目的 比較卡培他濱聯閤奧沙利鉑與奧沙利鉑單獨治療晚期結腸癌的療效.方法 將130例晚期結腸癌患者隨機分為觀察組和對照組,每組65例.觀察組採取卡培他濱聯閤奧沙利鉑治療,對照組使用奧沙利鉑單獨治療.觀察兩組治療後的療效、治療前後卡式功能狀態評分、生存時間、1.5年病死率和不良反應情況,以評價兩種治療方法的效果.結果 觀察組完全緩解、部分緩解、穩定、噁化患者分彆有9、22、26和8例,治療總有效率為47.69％,疾病控製率為87.69％,相比于對照組的29.23％和67.69％,差異有統計學意義(P＜0.05).觀察組生存時間明顯長于對照組,1.5年病死率顯著低于對照組(P＜0.05).兩組治療前後KPS功能評分和不良反應髮生率比較差異無統計學意義(P＞0.05).結論 相比于單獨使用奧沙利鉑,卡培他濱聯閤奧沙利鉑治療晚期結腸癌可以顯著提升療效,改善患者預後,值得在臨床中推廣使用.
목적 비교잡배타빈연합오사리박여오사리박단독치료만기결장암적료효.방법 장130례만기결장암환자수궤분위관찰조화대조조,매조65례.관찰조채취잡배타빈연합오사리박치료,대조조사용오사리박단독치료.관찰량조치료후적료효、치료전후잡식공능상태평분、생존시간、1.5년병사솔화불량반응정황,이평개량충치료방법적효과.결과 관찰조완전완해、부분완해、은정、악화환자분별유9、22、26화8례,치료총유효솔위47.69％,질병공제솔위87.69％,상비우대조조적29.23％화67.69％,차이유통계학의의(P＜0.05).관찰조생존시간명현장우대조조,1.5년병사솔현저저우대조조(P＜0.05).량조치료전후KPS공능평분화불량반응발생솔비교차이무통계학의의(P＞0.05).결론 상비우단독사용오사리박,잡배타빈연합오사리박치료만기결장암가이현저제승료효,개선환자예후,치득재림상중추엄사용.
Objective To compare the effects of capecitabine combined with oxaliplatin and oxaliplatin monotherapy on patients with advanced colon cancer.Methods One hundred and thirty cases of advanced colon cancer were randomly divided into observation group and control group,with 65 cases in each group.Patients in observation group were given capecitabine combined with oxaliplatin therapy,and patients in control group were given oxaliplatin alone.The efficacy,KPS function scores before and after treatment,survival time,1.5 year mortality and adverse reactions were observed,in order to evaluate the effects of the two treatment methods.Results There were 9,22,26,8 patients with complete remission(CR),partial response (PR),stable (SD),deterioration (PD) in the observation group,respectively.The total effective rate was 47.69％,disease control rate was 87.69 ％,compared to the control group (29.23％ and 67.69％),there were significant differences(P ＜ 0.05).The survival time was significantly longer than that in control group,1.5 year mortality was significantly lower than that in control group (P ＜ 0.05).There were no significant differences in KPS function scores before and after treatment and incidence of adverse reactions (P ＞ 0.05).Conclusions Compared with oxaliplatin alone,capecitabine combined with oxaliplatin in the treatment of advanced colon cancer can significantly improve the efficacy and outcomes,it is worthy promoting in clinics.
