CAJ | 학술논문

目的探讨阿托伐他汀钙治疗慢性充血性心力衰竭的有效性和安全性.方法选取慢性充血性心力衰竭患者48例,随机均分为对照组(常规治疗)和观察组(在此基础上加用阿托伐他汀钙治疗).比较两组治疗前后心输出量(CO)、心脏指数(CI)、左室舒张末期内径(LVD)、左室后壁厚度(LVWP)、左室射血分数(LVEF)、治疗总有效率及不良反应发生率的差异.结果两组患者治疗后心功能均较治疗前不同程度改善(P＜0.05),观察组改善程度显著优于对照组(P＜0.05);观察组治疗总有效率为91.7％,显著高于对照组的66.7％ (P ＜0.05);两组患者不良反应发生率比较差异无统计学意义(P＞0.05).结论阿托伐他汀钙治疗慢性充血性心力衰竭疗效确切,能显著改善心功能,且不良反应少.
목적 탐토아탁벌타정개치료만성충혈성심력쇠갈적유효성화안전성.방법 선취만성충혈성심력쇠갈환자48례,수궤균분위대조조(상규치료)화관찰조(재차기출상가용아탁벌타정개치료).비교량조치료전후심수출량(CO)、심장지수(CI)、좌실서장말기내경(LVD)、좌실후벽후도(LVWP)、좌실사혈분수(LVEF)、치료총유효솔급불량반응발생솔적차이.결과 량조환자치료후심공능균교치료전불동정도개선(P＜0.05),관찰조개선정도현저우우대조조(P＜0.05);관찰조치료총유효솔위91.7％,현저고우대조조적66.7％ (P ＜0.05);량조환자불량반응발생솔비교차이무통계학의의(P＞0.05).결론 아탁벌타정개치료만성충혈성심력쇠갈료효학절,능현저개선심공능,차불량반응소.
Objective To investigate the efficacy and safety of atorvastatin calcium in the treatment of chronic congestive heart failure.Methods Forty-eight cases of chronic congestive heart failure were randomly divided into control group(received conventional therapy) and observation group(received atorvastatin calcium based on conventional therapy).Cardiac output(CO),cardiac index(CI),left ventricular end diastolic diameter(LVD),left ventricular posterior wall thickness(LVWP),left ventricular ejection fraction (LVEF) before and after treatment,total effective rate and adverse reactions rate of the two groups were compared.Results Cardiac function of the two groups after treatment was significantly improved than before (P ＜ O.05).The degree of improvement in observation group was significantly better than that in control group(P ＜0.05).The total effective rate of observation group was 91.7％,which was significantly higher than that of control group(66.7％,P ＜0.05).Adverse reactions rate of the two groups had no significant difference (P ＞ 0.05).Conclusions Atorvastatin calcium for the treatment of chronic congestive heart failure can ensure curative effect,improve cardiac function and reduce adverse reactions.