CAJ | 학술논문

目的探讨乳腺癌组织中突触核蛋白-γ(SNCG)的表达水平及临床意义.方法采用免疫组化SP法检测40例乳腺纤维腺瘤、45例导管内原位癌、96例浸润性导管癌三组患者的术后标本中SNCG蛋白的表达水平,并对结果进行分析.结果 SNCG在乳腺纤维腺瘤、导管内原位癌、浸润性导管癌三组乳腺组织中表达率分别为2.50％、31.11％、69.79％,组间比较差异有统计学意义(P＜0.01).96例乳腺浸润性导管癌中,SNCG表达率在伴腋窝淋巴结转移组(80.36％)高于无转移组(55.00％),差异有统计学意义(P＜0.05).在临床分期Ⅰ、Ⅱ、Ⅲ期中SNCG表达率依次为44.44％、71.93％、85.71％,呈逐渐升高趋势,且差异有统计学意义(P＜0.05).在不同年龄、肿瘤直径、C-erbB-2组间SNCG表达率差异均无统计学意义(P＞0.05).结论 SNCG参与了乳腺癌的发生、浸润及转移,有望成为乳腺癌的辅助诊断及预测肿瘤的侵袭转移能力的重要指标.
목적 탐토유선암조직중돌촉핵단백-γ(SNCG)적표체수평급림상의의.방법 채용면역조화SP법검측40례유선섬유선류、45례도관내원위암、96례침윤성도관암삼조환자적술후표본중SNCG단백적표체수평,병대결과진행분석.결과 SNCG재유선섬유선류、도관내원위암、침윤성도관암삼조유선조직중표체솔분별위2.50％、31.11％、69.79％,조간비교차이유통계학의의(P＜0.01).96례유선침윤성도관암중,SNCG표체솔재반액와림파결전이조(80.36％)고우무전이조(55.00％),차이유통계학의의(P＜0.05).재림상분기Ⅰ、Ⅱ、Ⅲ기중SNCG표체솔의차위44.44％、71.93％、85.71％,정축점승고추세,차차이유통계학의의(P＜0.05).재불동년령、종류직경、C-erbB-2조간SNCG표체솔차이균무통계학의의(P＞0.05).결론 SNCG삼여료유선암적발생、침윤급전이,유망성위유선암적보조진단급예측종류적침습전이능력적중요지표.
Objective To investigate the expression and clinical significance of Synuclein-γ (SNCG) in breast carcinoma.Methods Immunohistochemistry technique SP method was used to detect the expression of SNCG in postoperative specimens of 40 cases of breast fibroadenoma,45 cases of breast ductal carcinoma in situ and 96 cases of breast invasive ductal carcinoma.The results were analyzed.Results Among the three groups,the positive expression rate of SNCG was 2.50％,31.11％,69.79％ respectively,there were significant differences among the different groups (P ＜ 0.01).In 96 cases of invasive ductal carcinoma,SNCG was over-expressed significantly in the group with axillary lymph node metastasis (80.36％),compared with the group without metastasis (55.00％,P ＜0.05).The positive rate increased gradually (44.44％,71.93％,85.71％) with the progress of clinical stage (P ＜0.05).The expression of SNCG was not correlated with age,tumor size or C-erbB-2 (P ＞ 0.05).Conclusions SNCG participate in the invasion and metastasis of breast cancer.SNCG could be used as one important indicator for the diagnosis of breast cancer and prediction of invasion and metastasis of the tumor.