中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
10期
52-54
,共3页
前列地尔%雷公藤多苷片%糖尿病肾病
前列地爾%雷公籐多苷片%糖尿病腎病
전렬지이%뢰공등다감편%당뇨병신병
Alprostadil%Tripterygium glycosides tablet%Diabetic nephropathy
目的 观察前列地尔联合雷公藤多苷片治疗糖尿病肾病的疗效.方法 将75例糖尿病肾病患者随机分为对照组、前列地尔组和联合用药组(对照组基础上加用前列地尔及雷公藤多苷片).观察治疗前和治疗6、12周后24 h尿蛋白定量、血白蛋白、肾功能、肝功能、血常规等变化,同时观察药物的不良反应.结果 三组治疗前24 h尿蛋白定量比较差异无统计学意义(P＞0.05);治疗6、12周后各组尿蛋白均较治疗前降低,两治疗组组间比较差异均有统计学意义(P＜0.01),对照组组间比较差异无统计学意义(P＞0.05);且联合治疗组治疗6周后与对照组治疗6周后相比,差异有统计学意义(P＜0.05);联合治疗组治疗12周后与对照组治疗12周后相比,差异有统计学意义(P＜0.01).其余指标如血白蛋白、血肌酐等变化差异无统计学意义.结论 前列地尔联合雷公藤多苷片治疗蛋白尿效果明显,能明显降低糖尿病肾病患者蛋白尿,从而延缓肾功能进展.
目的 觀察前列地爾聯閤雷公籐多苷片治療糖尿病腎病的療效.方法 將75例糖尿病腎病患者隨機分為對照組、前列地爾組和聯閤用藥組(對照組基礎上加用前列地爾及雷公籐多苷片).觀察治療前和治療6、12週後24 h尿蛋白定量、血白蛋白、腎功能、肝功能、血常規等變化,同時觀察藥物的不良反應.結果 三組治療前24 h尿蛋白定量比較差異無統計學意義(P＞0.05);治療6、12週後各組尿蛋白均較治療前降低,兩治療組組間比較差異均有統計學意義(P＜0.01),對照組組間比較差異無統計學意義(P＞0.05);且聯閤治療組治療6週後與對照組治療6週後相比,差異有統計學意義(P＜0.05);聯閤治療組治療12週後與對照組治療12週後相比,差異有統計學意義(P＜0.01).其餘指標如血白蛋白、血肌酐等變化差異無統計學意義.結論 前列地爾聯閤雷公籐多苷片治療蛋白尿效果明顯,能明顯降低糖尿病腎病患者蛋白尿,從而延緩腎功能進展.
목적 관찰전렬지이연합뢰공등다감편치료당뇨병신병적료효.방법 장75례당뇨병신병환자수궤분위대조조、전렬지이조화연합용약조(대조조기출상가용전렬지이급뢰공등다감편).관찰치료전화치료6、12주후24 h뇨단백정량、혈백단백、신공능、간공능、혈상규등변화,동시관찰약물적불량반응.결과 삼조치료전24 h뇨단백정량비교차이무통계학의의(P＞0.05);치료6、12주후각조뇨단백균교치료전강저,량치료조조간비교차이균유통계학의의(P＜0.01),대조조조간비교차이무통계학의의(P＞0.05);차연합치료조치료6주후여대조조치료6주후상비,차이유통계학의의(P＜0.05);연합치료조치료12주후여대조조치료12주후상비,차이유통계학의의(P＜0.01).기여지표여혈백단백、혈기항등변화차이무통계학의의.결론 전렬지이연합뢰공등다감편치료단백뇨효과명현,능명현강저당뇨병신병환자단백뇨,종이연완신공능진전.
Objective To observe the effect of alprostadil combined with tripterygium glycosides tablet on diabetic nephropathy.Methods Seventy-five patients with diabetic nephropathy were randomly divided into control group,alprostadil group and combination group (with alprostadil and tripterygium glycosides tablet added on the basis of the control group).The changes of the 24 h urinary protein,serum albumin,renal function,liver function,blood routine before treatment and 6,12 weeks after the treatment were observed,and the side effects of drugs were observed.Results Twenty-four hours urinary protein quantitative had no significant difference among the three groups before treatment (P ＞0.05); After 6,12weeks of treatment,the urine protein were lower than those before treatment,and the two treatment groups had significant differences (P ＜ 0.01),but the control group had no significant difference (P ＞ 0.05).Compared with the control group,there was significant difference in treatment group after 6 weeks treatment (P ＜0.05),and there were obviously differences in treatment group after 12 weeks treatment (P ＜0.01).The changes of other indicators of serum albumin,serum creatinine had no significant differences.Conclusions Alprostadil combined with tripterygium glycosides tablet is very effective on DN proteinuria,which can significantly reduce proteinuria in patients with DN,thus delay the progression of renal function.
