国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
21期
3232-3234
,共3页
精蛋白合成人胰岛素注射液%门冬胰岛素30%甘精胰岛素%糖尿病
精蛋白閤成人胰島素註射液%門鼕胰島素30%甘精胰島素%糖尿病
정단백합성인이도소주사액%문동이도소30%감정이도소%당뇨병
Protamine synthetic human insulin injection%Insulin aspart 30%Glargine%Diabetes
目的 探讨不同时效胰岛素联合治疗糖尿病的临床疗效及安全性.方法 选择2013年1月至12月于我院就诊的120例2型糖尿病患者,简单随机分为试验组和对照组各60例.对照组单独使用精蛋白合成人胰岛素注射液(预混30R)或门冬胰岛素30,试验组采用白天注射另外两种胰岛素、晚上睡前再分别加用甘精胰岛素或地特胰岛素进行治疗.所有患者均在分组前及研究结束时化验糖化血红蛋白,治疗期间每天测空腹血糖、三餐前后2h血糖和睡前血糖,记录低血糖发生率.结果 两组治疗后所有血糖水平除对照组午餐后2h血糖外均较治疗前明显下降,差异有统计学意义(P＜0.05),其中试验组患者的血糖控制水平明显较对照组好,差异有统计学意义(P＜0.05);试验组患者的低血糖反应发生率为10％,对照组的低血糖反应发生率为25％,两组患者低血糖反应发生率相比较,差异有统计学意义(x2=4.2702,P=0.0388).结论 不同时效胰岛素联合治疗糖尿病有效,且低血糖发生率低,适合长期推广应用.
目的 探討不同時效胰島素聯閤治療糖尿病的臨床療效及安全性.方法 選擇2013年1月至12月于我院就診的120例2型糖尿病患者,簡單隨機分為試驗組和對照組各60例.對照組單獨使用精蛋白閤成人胰島素註射液(預混30R)或門鼕胰島素30,試驗組採用白天註射另外兩種胰島素、晚上睡前再分彆加用甘精胰島素或地特胰島素進行治療.所有患者均在分組前及研究結束時化驗糖化血紅蛋白,治療期間每天測空腹血糖、三餐前後2h血糖和睡前血糖,記錄低血糖髮生率.結果 兩組治療後所有血糖水平除對照組午餐後2h血糖外均較治療前明顯下降,差異有統計學意義(P＜0.05),其中試驗組患者的血糖控製水平明顯較對照組好,差異有統計學意義(P＜0.05);試驗組患者的低血糖反應髮生率為10％,對照組的低血糖反應髮生率為25％,兩組患者低血糖反應髮生率相比較,差異有統計學意義(x2=4.2702,P=0.0388).結論 不同時效胰島素聯閤治療糖尿病有效,且低血糖髮生率低,適閤長期推廣應用.
목적 탐토불동시효이도소연합치료당뇨병적림상료효급안전성.방법 선택2013년1월지12월우아원취진적120례2형당뇨병환자,간단수궤분위시험조화대조조각60례.대조조단독사용정단백합성인이도소주사액(예혼30R)혹문동이도소30,시험조채용백천주사령외량충이도소、만상수전재분별가용감정이도소혹지특이도소진행치료.소유환자균재분조전급연구결속시화험당화혈홍단백,치료기간매천측공복혈당、삼찬전후2h혈당화수전혈당,기록저혈당발생솔.결과 량조치료후소유혈당수평제대조조오찬후2h혈당외균교치료전명현하강,차이유통계학의의(P＜0.05),기중시험조환자적혈당공제수평명현교대조조호,차이유통계학의의(P＜0.05);시험조환자적저혈당반응발생솔위10％,대조조적저혈당반응발생솔위25％,량조환자저혈당반응발생솔상비교,차이유통계학의의(x2=4.2702,P=0.0388).결론 불동시효이도소연합치료당뇨병유효,차저혈당발생솔저,괄합장기추엄응용.
Objective To analyze the necessity and safety of combined use of different aging insulin.Methods 120 cases of type 2 diabetes were selected in our hospital from January to December 2013,they were randomly divided into a test group of 60 patients and a control group of 60 patients,the control group used protamine synthetic human insulin injection (pre-mixed 30R) or insulin aspart 30,while the experimental group before going to bed at night were added with insulin glargine or detemir.Then we observed glycated hemoglobin,fasting blood glucose measurements every day during treatment,before and after meals and at bedtime 2h blood glucose,and recorded incidence of hypoglycemia.Results After treatment,blood glucose decreased,the difference was statistically significant (P ＜ 0.05).Blood glucose in the test group was better than that of the control group,the difference was statistically significant (P ＜ 0.05),the incidence of low blood sugar reaction in the test was 10.0％,which was lower than that of the control group of 25.0％,and the difference was statistically significant (x 2--4.2702,P=0.0388).Conclusion Different aging insulin combination in the treatment of diabetic is effective,which has low incidence of hypoglycemia and worthy of long-term promotion and application.
