中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
21期
1-4
,共4页
维吾尔族%单纯收缩期高血压%晚期糖基化终产物%血流介导的内皮依赖性血管舒张功能%脉搏波传导速度
維吾爾族%單純收縮期高血壓%晚期糖基化終產物%血流介導的內皮依賴性血管舒張功能%脈搏波傳導速度
유오이족%단순수축기고혈압%만기당기화종산물%혈류개도적내피의뢰성혈관서장공능%맥박파전도속도
Uygur%Isolated systolic hypertension%Advanced glycation end products%Flow-mediated endothelium-dependent vasodilation function%Pulse wave velocity
目的 探讨维吾尔族老年单纯收缩期高血压(ISH)患者血清中晚期糖基化终产物(AGE)与血管内皮功能的相关性.方法 选取118例维吾尔族老年ISH患者作为ISH组,维吾尔族老年原发性高血压(EH)患者115例作为EH组,并选择年龄与之相匹配的维吾尔族血压正常人群(NT) 100例作为NT组.采用ELISA法测定AGE浓度;采用Griess法测定血清一氧化氮(NO)浓度.应用超声技术测定血流介导的内皮依赖性血管舒张功能(FMD),动脉硬化检测仪测定颈-股动脉脉搏波传导速度(cfPWV).采用直线相关分析及多元线性逐步回归分析法分析AGE与其他指标的相关性.结果 ISH组、EH组AGE、cfPWV水平均高于NT组(P均＜0.05),一氧化氮、FMD水平均低于NT组(P均＜0.05),ISH组AGE及cfPWV水平均高于EH组(P均＜0.05),ISH组一氧化氮、FMD均低于EH组(P均＜0.05).相关性分析表明,AGE与cfPWV呈正相关(P＜0.001);AGE与NO、FMD呈负相关(P均＜0.001).多元线性逐步回归分析显示NO、cfPWV及AGE对FMD均有明显影响.结论 维吾尔族老年ISH患者血清AGE水平明显升高,且与FMD呈负相关.
目的 探討維吾爾族老年單純收縮期高血壓(ISH)患者血清中晚期糖基化終產物(AGE)與血管內皮功能的相關性.方法 選取118例維吾爾族老年ISH患者作為ISH組,維吾爾族老年原髮性高血壓(EH)患者115例作為EH組,併選擇年齡與之相匹配的維吾爾族血壓正常人群(NT) 100例作為NT組.採用ELISA法測定AGE濃度;採用Griess法測定血清一氧化氮(NO)濃度.應用超聲技術測定血流介導的內皮依賴性血管舒張功能(FMD),動脈硬化檢測儀測定頸-股動脈脈搏波傳導速度(cfPWV).採用直線相關分析及多元線性逐步迴歸分析法分析AGE與其他指標的相關性.結果 ISH組、EH組AGE、cfPWV水平均高于NT組(P均＜0.05),一氧化氮、FMD水平均低于NT組(P均＜0.05),ISH組AGE及cfPWV水平均高于EH組(P均＜0.05),ISH組一氧化氮、FMD均低于EH組(P均＜0.05).相關性分析錶明,AGE與cfPWV呈正相關(P＜0.001);AGE與NO、FMD呈負相關(P均＜0.001).多元線性逐步迴歸分析顯示NO、cfPWV及AGE對FMD均有明顯影響.結論 維吾爾族老年ISH患者血清AGE水平明顯升高,且與FMD呈負相關.
목적 탐토유오이족노년단순수축기고혈압(ISH)환자혈청중만기당기화종산물(AGE)여혈관내피공능적상관성.방법 선취118례유오이족노년ISH환자작위ISH조,유오이족노년원발성고혈압(EH)환자115례작위EH조,병선택년령여지상필배적유오이족혈압정상인군(NT) 100례작위NT조.채용ELISA법측정AGE농도;채용Griess법측정혈청일양화담(NO)농도.응용초성기술측정혈류개도적내피의뢰성혈관서장공능(FMD),동맥경화검측의측정경-고동맥맥박파전도속도(cfPWV).채용직선상관분석급다원선성축보회귀분석법분석AGE여기타지표적상관성.결과 ISH조、EH조AGE、cfPWV수평균고우NT조(P균＜0.05),일양화담、FMD수평균저우NT조(P균＜0.05),ISH조AGE급cfPWV수평균고우EH조(P균＜0.05),ISH조일양화담、FMD균저우EH조(P균＜0.05).상관성분석표명,AGE여cfPWV정정상관(P＜0.001);AGE여NO、FMD정부상관(P균＜0.001).다원선성축보회귀분석현시NO、cfPWV급AGE대FMD균유명현영향.결론 유오이족노년ISH환자혈청AGE수평명현승고,차여FMD정부상관.
Objective To investigate the relationship between advanced glycation end products (AGE) and vascular endothelial function in Uygur elderly patients with isolated systolic hypertension (ISH).Methods One hundred and eighteen Uygur old patients with ISH were enrolled as the ISH group,115 patients with essential hypertension (EH) were enrolled as the EH group,another 100 agematched normotension (NT) people were chose as NT group.Serum AGE levels were measured by ELISA method,and serum Nitric oxide(NO) levels were measured by Griess method.The flow-mediated endothelium-dependent vasodilation function (FMD) was detected by ultrasound technology,and carotid-femoral pulse wave conduction velocity (cfPWV) was measured by automatic arteriosclerosis detector.The relationship between AGE and other indicators was analyzed by linear correlation analysis and multiple linear stepwise regression analysis.Results The levels of AGE and cfPWV in ISH group and EH group were higher(P all ＜ 0.05),while the levels of NO and FMD were lower than those in NT group (P all ＜ O.05).The levels of AGE and cfPWV in ISH group were higher than those in EH group (P all ＜ 0.05),while the levels of NO and FMD in ISH group were lower than those in EH group (P all ＜ 0.05).AGE was positively correlated with cfPWV (P ＜ 0.001),but was negatively correlated with NO and FMD (P all ＜ 0.001).Multiple linear regression analysis showed that NO,cfPWV and AGE all had influence on FMD.Conclusions The serum AGE level is significantly elevated in Uygur elderly patients with isolated systolic hypertension,and it is negatively correlated with FMD.
