中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
21期
59-61
,共3页
幽门螺杆菌%缺血性脑卒中%超敏C-反应蛋白%同型半胱氨酸
幽門螺桿菌%缺血性腦卒中%超敏C-反應蛋白%同型半胱氨痠
유문라간균%결혈성뇌졸중%초민C-반응단백%동형반광안산
Helicobacter pylori%Ischemic stroke%High sensitivity C reactive protein%Homocysteine
目的 探讨幽门螺杆菌(Hp)感染、超敏C-反应蛋白(Hs-CRP)及同型半胱氨酸(Hcy)水平与缺血性脑卒中的关系.方法 选择2010年11月至2012年11月确诊的缺血性脑卒中患者150例为研究对象,另选取同时间段进行常规体检的人群100例做为对照组.采用酶联免疫吸附法、散射比浊法和循环酶法检测HPIgG、Hs-CRP和Hcy的表达水平,分析Hp感染与血清Hs-CRP、Hcy表达水平之间的关系.结果 缺血性脑卒中患者Hp感染阳性率明显高于对照组,差异有统计学意义(80％ vs 39％,P＜0.05);Hp感染阳性缺血性脑卒中患者的血清Hs-CRP水平及Hcy水平明显高于Hp感染阴性患者,差异有统计学意义[(43.15±5.61) mg/L vs(28.69±2.13) mg/L、(26.21±5.83) mmol/L vs(16.82±6.31) mmol/L,P＜0.05];直线相关分析结果显示,HPIgG阳性率、Hs-CRP、Hcy表达水平和缺血性脑卒中病情分级呈正相关(r值分别为0.73、0.85、0.89,P均＜0.05).结论 Hp感染与Hs-CRP和Hcy水平升高可能在缺血性脑卒中的疾病发生、发展中起重要作用,三者可能是缺血性脑卒中发生的危险因素.
目的 探討幽門螺桿菌(Hp)感染、超敏C-反應蛋白(Hs-CRP)及同型半胱氨痠(Hcy)水平與缺血性腦卒中的關繫.方法 選擇2010年11月至2012年11月確診的缺血性腦卒中患者150例為研究對象,另選取同時間段進行常規體檢的人群100例做為對照組.採用酶聯免疫吸附法、散射比濁法和循環酶法檢測HPIgG、Hs-CRP和Hcy的錶達水平,分析Hp感染與血清Hs-CRP、Hcy錶達水平之間的關繫.結果 缺血性腦卒中患者Hp感染暘性率明顯高于對照組,差異有統計學意義(80％ vs 39％,P＜0.05);Hp感染暘性缺血性腦卒中患者的血清Hs-CRP水平及Hcy水平明顯高于Hp感染陰性患者,差異有統計學意義[(43.15±5.61) mg/L vs(28.69±2.13) mg/L、(26.21±5.83) mmol/L vs(16.82±6.31) mmol/L,P＜0.05];直線相關分析結果顯示,HPIgG暘性率、Hs-CRP、Hcy錶達水平和缺血性腦卒中病情分級呈正相關(r值分彆為0.73、0.85、0.89,P均＜0.05).結論 Hp感染與Hs-CRP和Hcy水平升高可能在缺血性腦卒中的疾病髮生、髮展中起重要作用,三者可能是缺血性腦卒中髮生的危險因素.
목적 탐토유문라간균(Hp)감염、초민C-반응단백(Hs-CRP)급동형반광안산(Hcy)수평여결혈성뇌졸중적관계.방법 선택2010년11월지2012년11월학진적결혈성뇌졸중환자150례위연구대상,령선취동시간단진행상규체검적인군100례주위대조조.채용매련면역흡부법、산사비탁법화순배매법검측HPIgG、Hs-CRP화Hcy적표체수평,분석Hp감염여혈청Hs-CRP、Hcy표체수평지간적관계.결과 결혈성뇌졸중환자Hp감염양성솔명현고우대조조,차이유통계학의의(80％ vs 39％,P＜0.05);Hp감염양성결혈성뇌졸중환자적혈청Hs-CRP수평급Hcy수평명현고우Hp감염음성환자,차이유통계학의의[(43.15±5.61) mg/L vs(28.69±2.13) mg/L、(26.21±5.83) mmol/L vs(16.82±6.31) mmol/L,P＜0.05];직선상관분석결과현시,HPIgG양성솔、Hs-CRP、Hcy표체수평화결혈성뇌졸중병정분급정정상관(r치분별위0.73、0.85、0.89,P균＜0.05).결론 Hp감염여Hs-CRP화Hcy수평승고가능재결혈성뇌졸중적질병발생、발전중기중요작용,삼자가능시결혈성뇌졸중발생적위험인소.
Objective To investigate the relationship between Helicobacter pylori infection,high sensitive C reactive protein,homocysteine and ischemic stroke.Methods From November 2010 to November 2012,150 patients with ischemic stroke newly diagnosed were selected as the study objects,and 100 people for routine check-up during the same time were selected as control group.Using enzyme-linked immunosorbent assay,scattering ratio turbidimetry and enzymatic cycling assay,the expression levels of HPIgG,Hs-CRP and Hcy were detected.The relationship between Hp infection and serum Hs-CRP,Hcy levels was analyzed.Results The Hp infection positive rate of patients with ischemic cerebral stroke was obviously higher than that of the patients in the control group,there were significant differences (80％ vs 39％,P ＜ 0.05) ; The serum Hs-CRP levels and Hcy levels of the ischemic stroke patients with Hp infection were higher than those without Hp infection,there were significant differences [(43.15 ± 5.61) mg/L vs (28.69 ± 2.13) mg/L,(26.21 ± 5.83) mmol/L vs(16.82 ±6.31)mmol/L,P ＜0.05].Linear correlation analysis showed that the positive rate of HPIgG,and the expression levels of Hs-CRP,Hcy were positively correlated with ischemic stroke (r =0.73,0.85,0.89,P ＜ 0.05).Conclusions Hp infection and elevated levels of Hs-CRP and Hcy may play an important role in the occurrence and development of ischemic stroke,they may be the risk factors of ischemic stroke.
