中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
22期
21-23
,共3页
陈永宏%王耀勇%任金龙%程继霞
陳永宏%王耀勇%任金龍%程繼霞
진영굉%왕요용%임금룡%정계하
MTLC%KI-67%c-Myc%P53%乳腺癌%免疫组化
MTLC%KI-67%c-Myc%P53%乳腺癌%免疫組化
MTLC%KI-67%c-Myc%P53%유선암%면역조화
MTLC%KI-67%c-Myc%P53%Breast cancer%Immunohistochemistry
目的 探讨MTLC在乳腺癌中的表达及临床意义.方法 选取乳腺癌标本20例作为研究组,切缘远端正常组织标本20例作为对照组,采用免疫组化方法检测组织中MTLC蛋白的表达情况.结果 研究组中MTLC表达量(4.40±2.16)明显低于对照组(7.35±1.18),差异有统计学意义(T=5.67,P=0.00);研究组中高分化组MTLC (5.75±2.25)与中低分化组(3.50±1.62)的表达之间的独立样本T检验分析差异有统计学意义(T=2.60,P=0.018).研究组中KI-67、c-Myc、P53表达量分别是(4.58±3.43)、(5.90±3.46)、(6.60±3.45),与MTLC (4.40±2.16)表达之间的相关分析呈负相关,差异有统计学意义(P＜0.05).结论 MTLC可以作为乳腺癌的肿瘤标志物,MTLC过度表达对乳腺癌的发生有促进作用,MTLC与KI-67、c-Myc、P53之间的表达呈负相关关系.
目的 探討MTLC在乳腺癌中的錶達及臨床意義.方法 選取乳腺癌標本20例作為研究組,切緣遠耑正常組織標本20例作為對照組,採用免疫組化方法檢測組織中MTLC蛋白的錶達情況.結果 研究組中MTLC錶達量(4.40±2.16)明顯低于對照組(7.35±1.18),差異有統計學意義(T=5.67,P=0.00);研究組中高分化組MTLC (5.75±2.25)與中低分化組(3.50±1.62)的錶達之間的獨立樣本T檢驗分析差異有統計學意義(T=2.60,P=0.018).研究組中KI-67、c-Myc、P53錶達量分彆是(4.58±3.43)、(5.90±3.46)、(6.60±3.45),與MTLC (4.40±2.16)錶達之間的相關分析呈負相關,差異有統計學意義(P＜0.05).結論 MTLC可以作為乳腺癌的腫瘤標誌物,MTLC過度錶達對乳腺癌的髮生有促進作用,MTLC與KI-67、c-Myc、P53之間的錶達呈負相關關繫.
목적 탐토MTLC재유선암중적표체급림상의의.방법 선취유선암표본20례작위연구조,절연원단정상조직표본20례작위대조조,채용면역조화방법검측조직중MTLC단백적표체정황.결과 연구조중MTLC표체량(4.40±2.16)명현저우대조조(7.35±1.18),차이유통계학의의(T=5.67,P=0.00);연구조중고분화조MTLC (5.75±2.25)여중저분화조(3.50±1.62)적표체지간적독립양본T검험분석차이유통계학의의(T=2.60,P=0.018).연구조중KI-67、c-Myc、P53표체량분별시(4.58±3.43)、(5.90±3.46)、(6.60±3.45),여MTLC (4.40±2.16)표체지간적상관분석정부상관,차이유통계학의의(P＜0.05).결론 MTLC가이작위유선암적종류표지물,MTLC과도표체대유선암적발생유촉진작용,MTLC여KI-67、c-Myc、P53지간적표체정부상관관계.
Objective To investigate the role of MTLC in breast cancer.Methods Twenty cases of breast cancer in Shanxi Province Fenyang Hospital were selected in this study.Twenty cases of breast normal tissues were collected as control group.Immunohistochemical staining was performed to detect the expression of MTLC protein in 20 cases of breast cancer and 20 cases of breast normal tissues.Results By immunohistochemical staining,MTLC was mainly expressed in the nucleus and cytoplasm.The protein expression index of MTLC in breast cancer (4.40 ±2.16) was significantly lower than that of control qroup[(7.35 ± 1.18),t =5.67,P ＜ 0.O1].The protein expression index (5.75 ± 2.25) of MTLC was higher in differentiation group than that in moderate and low differentiation group [(3.50 ±1.62),t =2.60,P =0.018].The protein expression index of KI-67,c-Myc,P53 was (4.58 ± 3.43),(5.90 ± 3.46),(6.60 ± 3.45),respectively.The protein expression index of KI-67,c-Myc,P53 was negatively correlated with that of MTLC in breast cancer (P ＜ 0.05).Conclusions MTLC protein can be used as tumor marker in breast cancer,the lower expression of MTLC may promote the occurrence of breast cancer.The expression of MTLC is negative correlated with that of KI-67,c-Myc,P53
