CAJ | 학술논문

背景各种原因造成的组织器官血液灌流量减少或血流被完全阻断可使细胞发生缺血性损伤,近年来对脏器缺血性损伤的研究在细胞因子领域得到了广泛开展,尤其是白细胞介素(interleukin,IL)-17在缺血性损伤中的作用逐步受到了关注. 目的对IL-17在脏器缺血性损伤中作用的最新研究进展做一综述,为临床基础研究提供理论依据. 内容介绍IL-17的细胞因子家族、基因调节、信号转导通路,重点阐述IL-17在脏器缺血性损伤中的研究进展. 趋向针对IL-17参与脏器缺血性损伤过程的作用靶点,一些药物或者疗法可能能够减轻或逆转脏器的缺血性损伤,这将成为以后临床基础研究的新重点.
배경 각충원인조성적조직기관혈액관류량감소혹혈류피완전조단가사세포발생결혈성손상,근년래대장기결혈성손상적연구재세포인자영역득도료엄범개전,우기시백세포개소(interleukin,IL)-17재결혈성손상중적작용축보수도료관주. 목적 대IL-17재장기결혈성손상중작용적최신연구진전주일종술,위림상기출연구제공이론의거. 내용 개소IL-17적세포인자가족、기인조절、신호전도통로,중점천술IL-17재장기결혈성손상중적연구진전. 추향 침대IL-17삼여장기결혈성손상과정적작용파점,일사약물혹자요법가능능구감경혹역전장기적결혈성손상,저장성위이후림상기출연구적신중점.
Background Ischemic organ injury occurs when the blood supply to an organ is either partially or totally cut off.More and more attention were paid to recent studies about the effects of interleukin-17 on ischemic organ injury.Objective To provide theoretic basis for clinical and basic research by reviewing the recent advances of the effects of IL-17 on ischaemic organ injury.Content In this article,IL-17 cytokine family,gene regulation and signaling pathway of IL-17 will be reviewed.And the recent advances of the effects of IL-17 on ischaemic organ injury will be emphasized.Trend According to the effect targets of IL-17 participating in the process of ischemic organ injury,some drugs or therapies may be able to reduce or reverse ischemic organ injury.This will be a new focus of clinical and basic research.