CAJ | 학술논문

背景全身麻醉应用于临床已有160多年的历史,但麻醉药导致相应的行为改变如意识丧失、遗忘和镇痛的神经生理机制是什么,至今仍不清楚,尤其对于其中最具特征性的全麻意识消失,人们对其了解最为肤浅. 目的综述全身麻醉药对离子通道和受体、各脑电活动的影响和脑功能的变化. 内容全麻机制的研究可以分6个层次,分别是:分子水平、突触水平、细胞水平、神经微环路水平、系统水平(脑区)以及行为水平.总结近年来全身麻醉药(以下简称全麻药)在不同结构水平研究的最新进展,并从宏观上探讨全麻药对脑功能的影响. 趋向多种实验技术相结合将为全麻机制的研究提供新的方法.
배경 전신마취응용우림상이유160다년적역사,단마취약도치상응적행위개변여의식상실、유망화진통적신경생리궤제시십요,지금잉불청초,우기대우기중최구특정성적전마의식소실,인문대기료해최위부천. 목적 종술전신마취약대리자통도화수체、각뇌전활동적영향화뇌공능적변화. 내용 전마궤제적연구가이분6개층차,분별시:분자수평、돌촉수평、세포수평、신경미배로수평、계통수평(뇌구)이급행위수평.총결근년래전신마취약(이하간칭전마약)재불동결구수평연구적최신진전,병종굉관상탐토전마약대뇌공능적영향. 추향 다충실험기술상결합장위전마궤제적연구제공신적방법.
Background The clinical application of general anesthesia has been used for more than 160 years,however,neurophysiological mechanism of corresponding behavioral changes caused by anesthetic such as loss of consciousness,amnesia and analgesic are still unclear,especially for the unconsciousness which we hardly understood.Objective We reviewed the impacts of general anesthetics on ion channels and corresonding receptors,as well as brain electrical activity and changes in brain functions.Content The research of general anesthesia mechanisms can be divided into six levels:the molecular,synaptic,cellular,neural micro-circuit,system (brain areas) and behavioral level.This review summarized the progress about general anesthetics on different levels and explored the change of brain functions by general anesthetics on macro level.Trend The combination of different kinds of experimental techniques could provide new approaches for general anesthesia mechanism.