CAJ | 학술논문

背景非去极化肌肉松驰药(nondepolarizing muscle relaxations,NDMRs)在临床麻醉及重症监护应用广泛,其作用靶点位于神经肌肉接头(neuromuscular junctions,NMJs)突触后膜的肌肉型乙酰胆碱受体(muscle-nicotinic acetylcholine receptor,m-nAChR),多种因素可影响其临床药效. 目的阐述影响NDMRs效能的有关m-nAChR改变的因素,为临床麻醉用药提供参考. 内容乙酰胆碱受体质和量的改变,包括受体的数量、分布密度、脱敏、磷酸化、构象和亲和力、离子通道阻滞的改变以及脂质和ATP对受体的影响等,都将影响NDMRs效能. 趋向希望为探讨NDMRs效能变化的机制提供思路.
배경 비거겁화기육송치약(nondepolarizing muscle relaxations,NDMRs)재림상마취급중증감호응용엄범,기작용파점위우신경기육접두(neuromuscular junctions,NMJs)돌촉후막적기육형을선담감수체(muscle-nicotinic acetylcholine receptor,m-nAChR),다충인소가영향기림상약효. 목적 천술영향NDMRs효능적유관m-nAChR개변적인소,위림상마취용약제공삼고. 내용 을선담감수체질화량적개변,포괄수체적수량、분포밀도、탈민、린산화、구상화친화력、리자통도조체적개변이급지질화ATP대수체적영향등,도장영향NDMRs효능. 추향 희망위탐토NDMRs효능변화적궤제제공사로.
Background The non-depolarizing muscular relaxants (NDMRs) are used widely in genegral anesthesia and intensive care.The muscle-type nicotinic acetylcholine receptor (m-nAChR) site on the postsynaptic membrane of neuromuscular junctions (NMJs) is the target location of the NDMRs.Many factors can affect the potency of NDMRs.Objective This review is to investigate the factors of changing of the m-nAchRs which can affect the potency of NDMRs and provide reference to clinical anesthetic medication.Content All the changes of the quality and quantity of m-nAchR,including the quantity,density,desensitization,phosphorylation,conformation and affinity of the m-nAchR as well as the state of opening or closing about the ion channels the effect of cholesterin、adenosine triphosphate (ATP) and so on,will affect the potency of NDMRs.Trend To provide some opinions to investigate the mechanisms of affecting the potency of NDMRs.