CAJ | 학술논문

目的回顾性分析727例不同年龄组两种内膜准备方案的冻胚移植(FET)结局,探索不同年龄患者更适合的内膜准备方案.方法按不同年龄分为:Ⅰ组:＜25岁；Ⅱ组:25～29岁；Ⅲ组:30～34岁；Ⅳ组:35～39岁；Ⅴ组:≥40岁.按照内膜准备方案分为:自然周期组(A组)和激素替代周期组(B组),比较自然周期和激素替代周期各年龄组之间妊娠结局的差异.结果 A、B两组患者的临床妊娠率比较差异有统计学意义(P＜0.05)；自然周期的临床妊娠率随年龄的增长逐渐下降,但两组患者不同年龄组的胚胎种植率、临床妊娠率和流产率比较差异均无统计学意义(P＞0.05).结论对年龄偏大的患者行冻融胚胎移植时更倾向于应用激素替代周期来准备内膜.
목적 회고성분석727례불동년령조량충내막준비방안적동배이식(FET)결국,탐색불동년령환자경괄합적내막준비방안.방법 안불동년령분위:Ⅰ조:＜25세；Ⅱ조:25～29세；Ⅲ조:30～34세；Ⅳ조:35～39세；Ⅴ조:≥40세.안조내막준비방안분위:자연주기조(A조)화격소체대주기조(B조),비교자연주기화격소체대주기각년령조지간임신결국적차이.결과 A、B량조환자적림상임신솔비교차이유통계학의의(P＜0.05)；자연주기적림상임신솔수년령적증장축점하강,단량조환자불동년령조적배태충식솔、림상임신솔화유산솔비교차이균무통계학의의(P＞0.05).결론 대년령편대적환자행동융배태이식시경경향우응용격소체대주기래준비내막.
Objective To retrospectively analyze the outcomes of 727 patients of different ages with two kinds of endometrial preparation protocols for frozen embryo transfer,and to investigate more suitable endometrial preparation protocols.Methods Firstly,the patients were divided into 5 groups according to the different age:＜ 25 years old; 25-29 years old; 30-34 years old; 35-39 years old; ≥40 years old.Secondly,according to the endometrial preparation protocols,the patients were divided into:natural cycle group (group A) and hormone replacement cycle group (group B),the pregnancy outcome in the natural cycle and hormone replacement cycle in each age groups were compared.Results The clinical pregnancy rate of the two groups had significant difference (P ＜ 0.05).The clinical pregnancy rate of natural cycle decreased gradually as the age grow,however,the embryo implantation rate,clinical pregnancy and miscarriage rates of the two groups of patients in different age had no statistical significance (P ＞ 0.05).Conclusions It is more inclined to use hormone replacement cycle to prepare the endometrium for the older patients undergoing frozen-thawed embryo transfer.