CAJ | 학술논문

目的探讨功能性消化不良(FD)患者抗抑郁治疗初期出现胃肠道不良反应的机制,评价抗抑郁药物在FD治疗中的安全性.方法将57例FD患者随机分为两组,研究组30例和对照组27例.前者给予SSRIs治疗,后者给予噻奈普汀治疗,于治疗后统计两组胃肠道不良反应的类型及发生率,并了解两种药物胃肠道不良反应与疗程的关系.结果研究组胃肠道不良反应发生率明显高于对照组,且多发生于治疗早期,随着治疗时间的延长,不良反应症状逐渐减轻.结论选择性5-羟色胺再摄取抑制剂(SSRIs)是一种新型的抗抑郁药,胃肠道不良反应的发生与胃肠道内环境的5-羟色胺浓度骤然增加有关,后者作用于胃肠道5-羟色胺受体亚型,引起各种胃肠道不良反应.
목적 탐토공능성소화불량(FD)환자항억욱치료초기출현위장도불량반응적궤제,평개항억욱약물재FD치료중적안전성.방법 장57례FD환자수궤분위량조,연구조30례화대조조27례.전자급여SSRIs치료,후자급여새내보정치료,우치료후통계량조위장도불량반응적류형급발생솔,병료해량충약물위장도불량반응여료정적관계.결과 연구조위장도불량반응발생솔명현고우대조조,차다발생우치료조기,수착치료시간적연장,불량반응증상축점감경.결론 선택성5-간색알재섭취억제제(SSRIs)시일충신형적항억욱약,위장도불량반응적발생여위장도내배경적5-간색알농도취연증가유관,후자작용우위장도5-간색알수체아형,인기각충위장도불량반응.
Objective To investigate the mechanism of gastrointestinal adverse reaction in the early antidepressant treatment of functional dyspepsia(FD) and evaluate the safety of antidepressant in the treatment of FD.Methods Fifty-seven FD patients were divided into two groups randomly,30 cases in the study group and 27 cases in the control group.The patients in study group were given selective serotonin reuptake inhibitors(SSRI),the patients in control group were given Tianeptine.The types and incidence of gastrointestinal adverse reaction were recorded and analyzed,meanwhile the relationship between gastrointestinal adverse reaction and the period of treatment was understanded.Results The incidence of gastrointestinal adverse reaction in the study group was obviously higher than that in the control group,and mostly happened in the earlier treatment.As the treatments going,the gastrointestinal adverse reaction reduced gradually.Conclusions SSRIs is a new antidepressant drug.In the treatments,sudden increasing of 5-TH in the gastrointestinal internal environment leads to the events of gastrointestinal adverse reaction.5-TH effects on 5-TH receptor in the gastrointestinal tract and causes all sorts of gastrointestinal adverse reaction.