CAJ | 학술논문

目的观察不同剂量叶酸对H型高血压患者血浆同型半胱氨酸水平的影响.方法选择150例H型高血压病患者随机分为A、B、C三组,每组50例.用药剂量:A组给予叶酸5 mg/d,B组给予叶酸10 mg/d,C组给予叶酸15 mg,连续给药4周,治疗前后检测血浆Hcy浓度.结果三组治疗后血浆Hcy浓度皆明显下降,前后自身比较差异有统计学意义(P＜0.001).三组间比较差异无统计学意义(P＞0.05).结论叶酸对降低H型高血压病患者血浆Hcy有明显效果,但叶酸＞5 mg/d后增加叶酸剂量对于降低Hcy程度无明显效果.
목적 관찰불동제량협산대H형고혈압환자혈장동형반광안산수평적영향.방법 선택150례H형고혈압병환자수궤분위A、B、C삼조,매조50례.용약제량:A조급여협산5 mg/d,B조급여협산10 mg/d,C조급여협산15 mg,련속급약4주,치료전후검측혈장Hcy농도.결과 삼조치료후혈장Hcy농도개명현하강,전후자신비교차이유통계학의의(P＜0.001).삼조간비교차이무통계학의의(P＞0.05).결론 협산대강저H형고혈압병환자혈장Hcy유명현효과,단협산＞5 mg/d후증가협산제량대우강저Hcy정도무명현효과.
Objective To observe the effect of different dose of folic acid on the plasma homocysteine in patients with hyperhomocysteinima-related hypertention.Methods One hundred and fifty patients with hyperhomocysteinima-related hypertention were randomly divided into 3 groups,50 cases in each group.Group A was given folic 5 mg/d; group B was given folic acid 10 mg/d; group C was given folic acid 15 mg/d; The plasma homocysteine(Hcy) concentration was detected before and after 4 weeks treatment.Results After 4 weeks treatment,the levels of plasma Hcy all significantly decreased in 3 groups(P all ＜ 0.001),compared with the level of prior treatment.But there was no difference among the 3 groups after the treatment (P all ＞ 0.05).Conclusions The plasma homocysteine in patients with hyperhomocysteinima-related hypertention was decreased after the treatment of folic acid.The degree of the homocysteine decreased has no relationship with dose of the medicine.